L1CAM (NM_000425) Human Recombinant Protein
SKU
TP311601
Recombinant protein of human L1 cell adhesion molecule (L1CAM), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 137.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000416 |
| Locus ID | 3897 |
| UniProt ID | P32004 |
| Cytogenetics | Xq28 |
| RefSeq Size | 4525 |
| RefSeq ORF | 3771 |
| Synonyms | CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1 |
| Summary | The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. provided by RefSeq, May 2013 |
| Protein Categories | ADC Targets, CAR-T Targets, CD Markers, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Axon guidance, Cell adhesion molecules (CAMs) |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "L1CAM" proteins (8)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH311601 | L1CAM MS Standard C13 and N15-labeled recombinant protein (NP_000416) | 10 ug |
$3,360.00
|
|
| LC400150 | Lyophilized L1CAM HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400150 | Transient overexpression lysate of L1 cell adhesion molecule (L1CAM), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| TP721329 | Human CD171/L1CAM Protein (C-His) | 25 ug |
$300.00
|
|
| TP721330 | Human CD171/L1CAM Protein (C-His-Avi) | 25 ug |
$300.00
|
|
| TP721331 | Biotinylated Human CD171/L1CAM Protein (C-His-Avi) | 25 ug |
$430.00
|
|
| TP721332 | PE Conjugated Human CD171/L1CAM Protein (C-His) | 25 ug |
$430.00
|
|
| TP721333 | APC Conjugated Human CD171/L1CAM Protein (C-His) | 25 ug |
$430.00
|
|
Citations
L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
Norman, Ter-Ovanesyan, Trieu et al
Nat Methods (2021) 18 (6), 631-634 DOI: 10.1038/s41592-021-01174-8
Norman, Ter-Ovanesyan, Trieu et al
Nat Methods (2021) 18 (6), 631-634 DOI: 10.1038/s41592-021-01174-8
Cited by 269
AI Summary: OriGene products, specifically the anti-L1CAM antibody (Cat# TA326535) and L1CAM cDNA clone (Cat# RC208442), were used to detect and validate L1CAM presence in human cerebrospinal fluid and plasma, supporting the study’s conclusion that L1CAM is not associated with extracellular vesicles in these biofluids.
Showing 1-1 of 1 papers.
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