TXNIP (NM_006472) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 43.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_006463 |
| Locus ID | 10628 |
| UniProt ID | Q9H3M7 |
| Cytogenetics | 1q21.1 |
| RefSeq Size | 2979 |
| RefSeq ORF | 1173 |
| Synonyms | ARRDC6; EST01027; HHCPA78; THIF; VDUP1 |
| Summary | This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. provided by RefSeq, Sep 2015 |
| Protein Categories | Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "TXNIP" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH310804 | TXNIP MS Standard C13 and N15-labeled recombinant protein (NP_006463) | 10 ug |
$3,360.00
|
|
| LC401945 | Lyophilized TXNIP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401945 | Transient overexpression lysate of thioredoxin interacting protein (TXNIP) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection
Kim, Byun, Kim et al
Int J Mol Sci (2020) 21 (24) DOI: 10.3390/ijms21249499
Kim, Byun, Kim et al
Int J Mol Sci (2020) 21 (24) DOI: 10.3390/ijms21249499
Cited by 33
AI Summary: OriGene’s recombinant FLAG-tagged TXNIP protein was used in in vitro assays to investigate TXNIP’s inhibitory effect on TAK1 activity, helping to elucidate the molecular mechanism by which TXNIP regulates IFN-γ production in NK cells during bacterial infection.
Snippet: TAK1 immunoprecipitates were incubated with 2.5 µg of recombinant HIS tagged MKK6 protein (ATGen, Seongnam, Korea) and recombinant FLAG-tagged TXNIP protein (1 µg or 2 µg, Origene Technologies, Rockville, MD, USA)
Showing 1-1 of 1 papers.
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