Fatty Acid Synthase (FASN) (NM_004104) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 273.2 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004095 |
| Locus ID | 2194 |
| UniProt ID | P49327 |
| Cytogenetics | 17q25.3 |
| RefSeq Size | 8481 |
| RefSeq ORF | 7533 |
| Synonyms | FAS; OA-519; SDR27X1 |
| Summary | The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Fatty acid biosynthesis, Insulin signaling pathway, Metabolic pathways |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Fatty Acid Synthase" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH308644 | FASN MS Standard C13 and N15-labeled recombinant protein (NP_004095) | 10 ug |
$3,360.00
|
|
| LC418211 | Lyophilized FASN HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY418211 | Transient overexpression lysate of fatty acid synthase (FASN) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
Liu, Shen, Liu et al
Nat Commun (2025) 16 (1), 1762 DOI: 10.1038/s41467-025-57099-9
Liu, Shen, Liu et al
Nat Commun (2025) 16 (1), 1762 DOI: 10.1038/s41467-025-57099-9
Cited by 29
AI Summary: OriGene’s Flag-FASN protein (TP308644) was used in this study to investigate the interaction between FASN and mutant p53, helping to demonstrate that FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation.
Snippet: The purified His-tagged proteins were immobilized on Ni-NTA agarose beads (QIAGEN) and incubated with purified Flag-FASN (TP308644, Origene). His protein alone;The tumor-suppressive function of p53 is frequently disrupted by mutations in cancers. Missense mutant p53 (mutp53) protein often stabilizes and accumulates to high levels in cancers to promote tumorigenesis through the gain-of-function (GOF) mechanism. …
Showing 1-1 of 1 papers.
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