alpha 2 Macroglobulin (A2M) (NM_000014) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 160.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000005 |
| Locus ID | 2 |
| UniProt ID | P01023 |
| Cytogenetics | 12p13.31 |
| RefSeq Size | 4678 |
| RefSeq ORF | 4422 |
| Synonyms | A2MD; CPAMD5; FWP007; S863-7 |
| Summary | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. provided by RefSeq, Nov 2016 |
| Protein Categories | Cytokines, Growth Factors, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Complement and coagulation cascades |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "alpha 2 Macroglobulin" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH307905 | A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005) | 10 ug |
$3,360.00
|
|
| LC424975 | Lyophilized A2M HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424975 | Transient overexpression lysate of alpha-2-macroglobulin (A2M) (as WB positive control) | 100 ug |
$436.00
|
|
| TP701046 | Purified recombinant protein of Human alpha-2-macroglobulin (A2M), with C-terminal His tag, secretory expressed in HEK293 cells, 50ug | 50 ug |
$900.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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