CD43 (SPN) (NM_003123) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 40.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_003114 |
| Locus ID | 6693 |
| UniProt ID | P16150 |
| Cytogenetics | 16p11.2 |
| RefSeq Size | 6911 |
| RefSeq ORF | 1200 |
| Synonyms | CD43; GALGP; GPL115; LSN |
| Summary | This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. provided by RefSeq, Sep 2017 |
| Protein Categories | ADC Targets, CD Markers, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CD43" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH304195 | SPN MS Standard C13 and N15-labeled recombinant protein (NP_003114) | 10 ug |
$3,360.00
|
|
| LC418888 | Lyophilized SPN HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC422249 | Lyophilized SPN HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY418888 | Transient overexpression lysate of sialophorin (SPN), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY422249 | Transient overexpression lysate of sialophorin (SPN), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
Malaker, Pedram, Ferracane et al
Proc Natl Acad Sci U S A (2019) 116 (15), 7278-7287 DOI: 10.1073/pnas.1813020116
Malaker, Pedram, Ferracane et al
Proc Natl Acad Sci U S A (2019) 116 (15), 7278-7287 DOI: 10.1073/pnas.1813020116
Cited by 299
AI Summary: In this study, OriGene's recombinant human mucin proteins (MUC1, MUC16, and MUC16-Fc) were used as substrates to assess the specificity and utility of the StcE protease in analyzing mucin domain structure and glycosylation.
Showing 1-1 of 1 papers.
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