Arg 3.1 (ARC) (NM_015193) Human Recombinant Protein
SKU
TP304129
Recombinant protein of human activity-regulated cytoskeleton-associated protein (ARC), 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 45.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_056008 |
| Locus ID | 23237 |
| UniProt ID | Q7LC44 |
| Cytogenetics | 8q24.3 |
| RefSeq Size | 2948 |
| RefSeq ORF | 1188 |
| Synonyms | Arg3.1; hArc |
| Summary | Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).UniProtKB/Swiss-Prot Function |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "Arg 3.1" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH304129 | ARC MS Standard C13 and N15-labeled recombinant protein (NP_056008) | 10 ug |
$3,360.00
|
|
| LC414716 | Lyophilized ARC HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY414716 | Transient overexpression lysate of activity-regulated cytoskeleton-associated protein (ARC) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Biophysical characterization of Arc protein-RNA interactions
Al Othman, Lupanova, Bagrov et al
Neuroreport (2026)
Al Othman, Lupanova, Bagrov et al
Neuroreport (2026)
AI Summary: OriGene's recombinant human Arc protein (TP304129) was used in this study to investigate how Arc binds to and assembles with its own mRNA, enabling detailed biophysical analyses of Arc protein-RNA interactions.
Snippet: Recombinant human Arc protein (TP304129, OriGene) at 100 μg mL−1 in low-salt buffer (20 mM NaCl, 50 mM Tris, pH 7.4, room temperature) was incubated with Arc
Retrovirus-Like Gag Protein Arc/Arg3.1 is Involved in Extracellular-Vesicle-Mediated mRNA Transfer between Glioma Cells
Al Othman, Bagrov, Rozenberg et al
Biochim Biophys Acta Gen Subj (2023) 1868 (1), 130522 DOI: 10.1016/j.bbagen.2023.130522
Al Othman, Bagrov, Rozenberg et al
Biochim Biophys Acta Gen Subj (2023) 1868 (1), 130522 DOI: 10.1016/j.bbagen.2023.130522
Cited by 7
AI Summary: OriGene’s recombinant Arc protein (Cat# TP304129) was used in this study to investigate the binding affinity of Arc protein to Arc mRNA, contributing to the understanding of Arc-mediated mRNA transfer between glioma cells.
Snippet: Then, biosensors were exposed to recombinant Arc protein (TP304129, OriGene) solution in the assay buffer at a concentration of 30 µg mL -1 of for 130 s. The
Showing 1-2 of 2 papers.
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