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PTEN (NM_000314) Human Recombinant Protein

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SKU
TP302627
Recombinant protein of human phosphatase and tensin homolog (PTEN), 20 µg
Size:
20 ug 1 mg 100 ug
  $737.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Recombinant protein was produced with TrueORF clone, RC202627. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 47 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000305
Locus ID 5728
UniProt ID P60484
Cytogenetics 10q23.31
RefSeq Size 5572
RefSeq ORF 1209
Synonyms 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; PTENbeta; TEP1
Summary This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. provided by RefSeq, Feb 2015
Protein Categories Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Haematopoietic and Lymphoid, Cancer: Lung, Cancer: Skin, Growth Factors, Intracellular Proteins
Protein Families Druggable Genome, Phosphatase
Protein Pathways Endometrial cancer, Focal adhesion, Glioma, Inositol phosphate metabolism, Melanoma, p53 signaling pathway, Pathways in cancer, Phosphatidylinositol signaling system, Prostate cancer, Small cell lung cancer, Tight junction
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Other "PTEN" proteins (5)
SKU Description Size Price
PH302627 PTEN MS Standard C13 and N15-labeled recombinant protein (NP_000305) 10 ug
$3,360.00
LC424803 Lyophilized PTEN HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY424803 Transient overexpression lysate of phosphatase and tensin homolog (PTEN) (as WB positive control) 100 ug
$436.00
TP710023 Recombinant protein of human phosphatase and tensin homolog (PTEN),full length, with N-terminal polyhistidine tag, expressed in sf9 cells. 20 ug
$540.00
TP762463 Purified recombinant protein of Human phosphatase and tensin homolog (PTEN), Asn228-End, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$240.00

file-alt Citations

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
Brosig, Fuchs, Ipek et al
Cell Rep (2019) 29 (7), 2028-2040.e8 DOI: 10.1016/j.celrep.2019.10.039
AI Summary: OriGene contributed to this study by providing the Human Recombinant PTEN protein (Cat# TP302627), which was used to investigate the interaction between PTEN and PRG2 in regulating axon growth and branching.
Snippet: ces Cat#P-4508 PTEN (GeneBank: {"type":"entrez-nucleotide","attrs":{"text":"NM_000314","term_id":"1732746392","term_text":"NM_000314"}}NM_000314 [/nuccore/NM_000314]) Human Recombinant Protein OriGene Cat#TP302627 Latrunculin B Millipore Cat#42820;CAS: 76343-94-7 LY294002 Millipore Cat#440202;CAS: 154447-36-6 Janelia Fluor 646 HaloTag ligand Promega Cat#GA1120 Hu;;... ces Cat#P-4508 PTEN (GeneBank: {"type":"entrez-nucleotide","attrs":{"text":"NM_000314","term_id":"1732746392","term_text":"NM_000314"}}NM_000314 [/nuccore/NM_000314]) Human Recombinant Protein OriGene Cat#TP302627 Latrunculin B Millipore Cat#42820
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