RAIDD (CRADD) (NM_003805) Human Recombinant Protein
SKU
TP302050
Recombinant protein of human CASP2 and RIPK1 domain containing adaptor with death domain (CRADD), 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 22.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_003796 |
| Locus ID | 8738 |
| UniProt ID | P78560 |
| Cytogenetics | 12q22 |
| RefSeq Size | 1201 |
| RefSeq ORF | 597 |
| Synonyms | MRT34; RAIDD |
| Summary | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "RAIDD" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH302050 | CRADD MS Standard C13 and N15-labeled recombinant protein (NP_003796) | 10 ug |
$3,360.00
|
|
| LC401252 | Lyophilized CRADD HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401252 | Transient overexpression lysate of CASP2 and RIPK1 domain containing adaptor with death domain (CRADD) (as WB positive control) | 100 ug |
$436.00
|
|
| TP720921 | Purified recombinant protein of Human CASP2 and RIPK1 domain containing adaptor with death domain (CRADD) | 10 ug |
$340.00
|
|
Citations
Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis
Nganga, Oleinik, Kim et al
J. Biol. Chem. (2018) 294 (2), 502-519 DOI: 10.1074/jbc.RA118.005865
Nganga, Oleinik, Kim et al
J. Biol. Chem. (2018) 294 (2), 502-519 DOI: 10.1074/jbc.RA118.005865
AI Summary: OriGene contributed to this study by providing full-length recombinant RIPK1, which was used to investigate the molecular interactions underlying ceramidosome formation and necroptosis.
Snippet: K858, Ciliobrevin (Tocris), Blebbistatin (Selleckchem), NSA (EMD Millipore), Sphingosine, (Avanti Polar Lipids), Fumonisin B1 (Enzo) Biotinylated C6-ceramide (Echelon Biosciences). Full length recombinant RIPK1 was purchased from Origene
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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