PDIA6 (NM_005742) Human Recombinant Protein
SKU
TP301710
Recombinant protein of human protein disulfide isomerase family A, member 6 (PDIA6), 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 47.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005733 |
| Locus ID | 10130 |
| UniProt ID | Q15084 |
| Cytogenetics | 2p25.1 |
| RefSeq Size | 2349 |
| RefSeq ORF | 1320 |
| Synonyms | ERP5; P5; TXNDC7 |
| Summary | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Dec 2016 |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PDIA6" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301710 | PDIA6 MS Standard C13 and N15-labeled recombinant protein (NP_005733) | 10 ug |
$3,360.00
|
|
| LC401760 | Lyophilized PDIA6 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401760 | Transient overexpression lysate of protein disulfide isomerase family A, member 6 (PDIA6) (as WB positive control) | 100 ug |
$436.00
|
|
| TP720679 | Purified recombinant protein of Human protein disulfide isomerase family A, member 6 (PDIA6) | 10 ug |
$275.00
|
|
Citations
Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
Stanton, Gad, Ramos et al
NPJ Breast Cancer (2021) 7 (1), 50 DOI: 10.1038/s41523-021-00257-1
Stanton, Gad, Ramos et al
NPJ Breast Cancer (2021) 7 (1), 50 DOI: 10.1038/s41523-021-00257-1
Cited by 12
AI Summary: OriGene products, specifically the human VPS35 (Cat# RC222447), ARPC2 (Cat# RC202766), SERBP1 (Cat# RC202062), KRT8 (Cat# RC200181), and PDIA6 (Cat# RC200853) Myc-DDK-tagged ORF cDNA clones, were used to express and study the candidate tumor antigens whose autoantibody responses were analyzed in both mouse models and human breast cancer patient serum.
Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes
Oliveira, Garcia-Rosa, Sachetto et al
Redox Biol (2019) 22, 101142 DOI: 10.1016/j.redox.2019.101142
Oliveira, Garcia-Rosa, Sachetto et al
Redox Biol (2019) 22, 101142 DOI: 10.1016/j.redox.2019.101142
Cited by 33
AI Summary: In this study, OriGene's Human P4HB (PDI) ELISA Kit (EA100907) was used to quantitatively measure plasma PDI levels, enabling the identification of distinct plasma proteome signatures associated with contrasting endothelial phenotypes in healthy individuals.
Proteína dissulfeto isomerase plasmática: detecção e correlação com assinaturas proteômicas ligadas a distintos fenótipos endoteliais em indivíduos saudáveis
Oliveira
Thesis (2019)
Oliveira
Thesis (2019)
Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes
de Oliveira, Garcia-Rosa, Sachetto
Redox Biology (2019)
de Oliveira, Garcia-Rosa, Sachetto
Redox Biology (2019)
AI Summary: OriGene’s recombinant Erp57 (TP305940) and ERp5 (TP301710) proteins were used as reference standards in the analysis of plasma samples, enabling the study to accurately detect and quantify PDI family proteins and assess their association with distinct endothelial phenotypes.
Snippet: … Platelet-poor plasma (no dilution), recombinant PDI solutions (reduced, oxidized, S-nitrosylated), human cell lysates, conditioned medium, and recombinant Erp57 (OriGene-TP305940) and ERp5 (OriGene-TP301710) were analyzed. 2.3 PDI purification Histidine-tagged full length human PDI was cloned into the pET28a vector (Novagen) and overexpressed in E. coli strai;;... … Platelet-poor plasma (no dilution), recombinant PDI solutions (reduced, oxidized, S-nitrosylated), human cell lysates, conditioned medium, and recombinant Erp57 (OriGene-TP305940) and ERp5 (OriGene-TP301710) were analyzed. 2.3 PDI purification Histidine-tagged full length human PDI was cloned into the pET28a vector (Novagen) and overexpressed in E. coli strai;Platelet-poor plasma (no dilution), recombinant PDI solutions (reduced, oxidized, S-nitrosylated), human cell lysates, conditioned medium, and recombinant Erp57 (OriGene-TP305940) and ERp5 (OriGene-TP301710) were analyzed. 2.3. …
Showing 1-4 of 4 papers.
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