CIRBP (NM_001280) Human Recombinant Protein
SKU
TP301639
Recombinant protein of human cold inducible RNA binding protein (CIRBP), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 18.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001271 |
| Locus ID | 1153 |
| UniProt ID | Q14011 |
| Cytogenetics | 19p13.3 |
| RefSeq Size | 1397 |
| RefSeq ORF | 516 |
| Synonyms | CIRP |
| Summary | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3' UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.UniProtKB/Swiss-Prot Function |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CIRBP" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301639 | CIRBP MS Standard C13 and N15-labeled recombinant protein (NP_001271) | 10 ug |
$3,360.00
|
|
| LC420029 | Lyophilized CIRBP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY420029 | Transient overexpression lysate of cold inducible RNA binding protein (CIRBP), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons
Sharma, Brenner, Jacob et al
Mol Neurobiol (2021)
Sharma, Brenner, Jacob et al
Mol Neurobiol (2021)
Cited by 30
AI Summary: In this study, OriGene's recombinant human CIRP (rhCIRP) protein with a C-terminal DDK tag, expressed in HEK293T cells, was used to investigate the binding of eCIRP to its neuronal receptor IL-6Rα and to assess the molecular mechanisms underlying eCIRP-induced neuroinflammation.
Snippet: rhCIRP with C-terminal DDK tag, transfected and expressed from human HEK293T cells was obtained from Origene (Rockville, Maryland) binding analyses. To evaluate the binding, the analyte rhCIRP protein (Origene) (500 nM for yes or no
Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1
Liu, Ke, Wang et al
J Cell Mol Med (2021)
Liu, Ke, Wang et al
J Cell Mol Med (2021)
Cited by 17
AI Summary: OriGene's pCMV6-Myc-DDK expression vectors were used to clone and overexpress Cirp, Cav1, and Cavin1 cDNAs in rat pulmonary artery endothelial cells, enabling functional studies of these genes in pulmonary artery hypertension.
Snippet: Page 3. | 3 LIU et aL. For overexpression, Cirp, Cav1 and Cavin1 cDNAs were cloned into pCMV6 tagged with Myc and DDK (Origene), and verified by Sanger sequencing. The constructs were transfected into rPAECs with Lipofectamine 3000 (Invitrogen);- Page 3. | 3 LIU et aL. For overexpression, Cirp, Cav1 and Cavin1 cDNAs were cloned into pCMV6 tagged with Myc and DDK (Origene), and verified by Sanger sequencing. …
A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF
Choi, Xu, Makowski et al
Nat Genet (2017) 49 (9), 1326-1335 DOI: 10.1038/ng.3927
Choi, Xu, Makowski et al
Nat Genet (2017) 49 (9), 1326-1335 DOI: 10.1038/ng.3927
Cited by 68
AI Summary: In this paper, OriGene products—specifically the PARP1 cDNA clone (RC204232) and PARP1 shRNA (TL309386)—were used to modulate PARP1 expression in melanocyte experiments, enabling the authors to investigate how PARP1 influences cell proliferation and senescence in the context of melanoma risk.
Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis
Qiang, Yang, Wu et al
Nat. Med. (2013)
Qiang, Yang, Wu et al
Nat. Med. (2013)
Cited by 463
AI Summary: OriGene’s recombinant human CIRP (rhCIRP, NP_001271; full length with C-terminal DDK tag) was used in this study to investigate CIRP’s role in triggering inflammatory responses in hemorrhagic shock and sepsis.
Showing 1-4 of 4 papers.
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