UMPS (NM_000373) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 52 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | UMPS activity is verified in a bioassay: |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000364 |
| Locus ID | 7372 |
| UniProt ID | P11172 |
| Cytogenetics | 3q21.2 |
| RefSeq Size | 6738 |
| RefSeq ORF | 1440 |
| Synonyms | OPRT |
| Summary | This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. provided by RefSeq, Mar 2010 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "UMPS" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301324 | UMPS MS Standard C13 and N15-labeled recombinant protein (NP_000364) | 10 ug |
$3,360.00
|
|
| LC424757 | Lyophilized UMPS HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424757 | Transient overexpression lysate of uridine monophosphate synthetase (UMPS) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells
Bardeleben, Sharma, Reeve et al
Mol. Cancer Ther. (2013) 12 (7), 1310-21 DOI: 10.1158/1535-7163.MCT-12-1042
Bardeleben, Sharma, Reeve et al
Mol. Cancer Ther. (2013) 12 (7), 1310-21 DOI: 10.1158/1535-7163.MCT-12-1042
AI Summary: OriGene's recombinant UMP synthetase was used in this study to investigate the mechanism of UMP synthetase inhibition and pyrimidine starvation in multiple myeloma cells treated with AICAr.
Snippet: Recombinant UMP synthetase was purchased from Origene and recombinant APRTase was purchased from Prospec. [6- ... 5D). Mechanism of UMPS inhibition and pyrimidine starvation Although unlikely, based on the long half-life of UMP synthetase (32), one possibility
Showing 1-1 of 1 papers.
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