M6PR (NM_002355) Human Recombinant Protein
SKU
TP301277
Recombinant protein of human mannose-6-phosphate receptor (cation dependent) (M6PR), 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 27.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002346 |
| Locus ID | 4074 |
| UniProt ID | P20645 |
| Cytogenetics | 12p13.31 |
| RefSeq Size | 2583 |
| RefSeq ORF | 831 |
| Synonyms | CD-M6PR; CD-MPR; MPR-46; MPR 46; MPR46; SMPR |
| Summary | This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. provided by RefSeq, May 2011 |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "M6PR" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301277 | M6PR MS Standard C13 and N15-labeled recombinant protein (NP_002346) | 10 ug |
$3,360.00
|
|
| LC419372 | Lyophilized M6PR HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419372 | Transient overexpression lysate of mannose-6-phosphate receptor (cation dependent) (M6PR) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
M6PR- and EphB4-Rich Exosomes Secreted by Serglycin-Overexpressing Esophageal Cancer Cells Promote Cancer Progression
Yan, Cui, Zhu et al
Int. J. Biol. Sci. (2023) 19 (2), 625-640 DOI: 10.7150/ijbs.79875
Yan, Cui, Zhu et al
Int. J. Biol. Sci. (2023) 19 (2), 625-640 DOI: 10.7150/ijbs.79875
Cited by 25
AI Summary: OriGene’s human recombinant M6PR protein (rhM6PR, #TP301277) was used in this study to assess the role of M6PR in promoting angiogenesis in vivo by injecting it into mice as part of matrigel plug assays.
Snippet: Briefly, 300 μL growth factor reduced matrigel (#356231, Corning) containing 6480 U/mL heparin (#H3149, Sigma-Aldrich) and 2 × 108 exosomes or ~ 12 ug/mL human recombinant M6PR (rhM6PR, #TP301277, OriGene, Rockville, MD, USA) was subcutaneously injected into the flank of C57BL/6 mice (n = 4 per group). After 7 days, the matrigel plugs were harvested for hemoglobin quantification using Drabkin's
Showing 1-1 of 1 papers.
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