PSMC5 (NM_002805) Human Recombinant Protein

CAT#: TP301251

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Recombinant protein of human proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5)


 Product Datasheet for 'TP301251'

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USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 45.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_002796
Locus ID 5705
Refseq Size 1372
Cytogenetics 17q23.3
Refseq ORF 1218
Synonyms p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Protein Families Druggable Genome
Protein Pathways Proteasome

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