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GRB2 (NM_002086) Human Recombinant Protein

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SKU
TP300469
Recombinant protein of human growth factor receptor-bound protein 2 (GRB2), transcript variant 1, 20 µg
Size:
20 ug 1 mg 100 ug
  $737.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC200469 protein sequence
Red=Cloning site Green=Tags(s)

MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKA
EEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSV
SRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV
TPVNRNV

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 25 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002077
Locus ID 2885
UniProt ID P62993
Cytogenetics 17q25.1
RefSeq Size 3303
RefSeq ORF 651
Synonyms ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2
Summary The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008
Protein Categories Growth Factors, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Renal cell carcinoma, T cell receptor signaling pathway
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Other "GRB2" proteins (6)
SKU Description Size Price
PH300469 GRB2 MS Standard C13 and N15-labeled recombinant protein (NP_002077) 10 ug
$3,360.00
LC400765 Lyophilized GRB2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC404254 Lyophilized GRB2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400765 Transient overexpression lysate of growth factor receptor-bound protein 2 (GRB2), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY404254 Transient overexpression lysate of growth factor receptor-bound protein 2 (GRB2), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP720535 Recombinant protein of human growth factor receptor-bound protein 2 (GRB2), transcript variant 1 10 ug
$340.00

file-alt Citations

Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex
Gregor, Bosakova, Nita et al
Cell. Mol. Life Sci. (2019)
Cited by 18
AI Summary: OriGene products contributed GRB2 (RC200469), p85a-PI3K (RG210544), and SHIP2 (RC214716) expression vectors, which were used to study protein interactions within the BCR-ABL signaling complex in this research.
Snippet: … GRB2 (RC200469), p85a-PI3K (RG210544) and SHIP2 (RC214716) vectors were obtained from Origene, CRKL (HG11261-CH) and STS1 (HG13868-NF) vectors were obtained from Sino Biological. …
Showing 1-1 of 1 papers.
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