Complement factor B (26-259, His-Tag) Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | His-Tag |
| Predicted MW | 28.4 kDa (257aa) |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea |
| Preparation | Liquid purified protein |
| Recommended Dilution | SDS-PAGE,Denatured |
| Protein Description | Recombinant human CFB protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_001701 |
| Locus ID | 629 |
| UniProt ID | P00751 |
| Cytogenetics | 6p21.33 |
| Synonyms | complement factor B preproprotein, AHuS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2 |
| Summary | This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. provided by RefSeq, Jul 2008 |
| Protein Categories | Cardiovascular diseases, Enzyme: Peptidases, Immune system diseases, Nervous system Diseases, Secreated Proteins |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Protein Pathways | Complement and coagulation cascades |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Citations
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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