Neutrophil elastase Human Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Protein Source | Neutrophils |
| Concentration | lot specific |
| Purity | >95% pure by SDS-PAGE |
| Presentation State | Purified |
| Buffer | Presentation State: Purified State: Lyophilized purified protein containing no preservatives. |
| Reconstitution Method | Restore with 50mM Sodium Acetate, pH 5.5 containing 150mM Sodium Chloride. |
| Preparation | Lyophilized purified protein containing no preservatives. |
| Protein Description | Human Neutrophil Elastase. |
| Note | Caution: Prepared from whole blood shown to be nonreactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA licensed tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious. |
| Storage | Store the antigen at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: six months from despatch. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_001963 |
| Locus ID | 1991 |
| Cytogenetics | 19p13.3 |
| Synonyms | ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE |
| Summary | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. provided by RefSeq, Jan 2016 |
| Protein Categories | Chemokines, Cytokines, Enzyme: Peptidases, Immune system diseases, Secreated Proteins |
| Protein Families | Protease, Transmembrane |
| Protein Pathways | Systemic lupus erythematosus |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
