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Plasmin Human Protein

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SKU
BA1079
Plasmin human protein, 1 mg
Size:
1 mg
  $435.00
2 Weeks*
Bulk/Customize

Other products for "PLG or NM_000301"

Specifications
Specifications
Product Data
Species Human
Protein Source Plasma
Concentration lot specific
Purity >95%
Presentation State Purified
Buffer Presentation State: Purified
State: Liquid purified protein.
Buffer System: 100 mM Sodium Phosphate, pH 7.3 containing 1 mM 6-Aminohexanoic Acid and 25% Glycerol.
Preservative: None
Bioactivity Specific: 19.7 units per mg prior to freezing.
One unit is defined as the amount of enzyme that will hydrolyze 1 µmole of tosyl-Gly-Pro-Lys-pNA per minute at 25°C, pH 7.8.
Note: One unit = 1.25 CU.
Preparation Liquid purified protein.
Protein Description Purified Human Plasmin Protein.
Note Caution: All human source materials have tested negative for HIV 1, HIV 2, anti-HCV, anti-HBc antibodies, and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Storage Upon receipt, store (in aliquots) at -20°C to -80°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Dry Ice
Reference Data
RefSeq NP_000292
Locus ID 5340
Cytogenetics 6q26
Synonyms HAE4
Summary The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. provided by RefSeq, May 2020
Protein Categories Cardiovascular diseases, Enzyme: Peptidases, Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades, Neuroactive ligand-receptor interaction
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Documents
Resources

file-alt Citations

Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents
Teye, Numata, Ishii et al
PLoS One (2016) 11 (8), e0160952 DOI: 10.1371/journal.pone.0160952
Cited by 13
AI Summary: OriGene products contributed to this study by providing the CD44 cDNA clones (OriGene, Cat# SC119282), which were used for the cloning and sequence analysis of CD44 transcripts in human epidermis.
FigureFigureFigure
Showing 1-1 of 1 papers.
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