LRRC8 (R262W）
SKU
TP701137
Purified recombinant protein of Human LRRC8/8A-8C (ECL), with C-terminal Myc-DDK tag, expressed in HEK293 cells, 20ug
$900.00
5 Days*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 94.2 kDa |
| Concentration | >0.05 µg/µL as determined by microplate Bradford method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, and 10% glycerol, pH 7.3 |
| Note | For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Ship with Dry ice. Store at -80℃ after receiving vials. |
| Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| Synonyms | LRRC8 8A-8C ECL |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function
Yamada, Strange
J. Gen. Physiol. (2018)
Yamada, Strange
J. Gen. Physiol. (2018)
AI Summary: OriGene products, specifically human LRRC8A, LRRC8C, LRRC8D, and LRRC8E cDNAs cloned into pCMV6 (catalog numbers RC226180, RC222603, RC203641, and RC209849), were used as essential tools for expressing and manipulating VRAC subunits to investigate the structural requirements for channel function in this study.
Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish
Yamada, Wondergem, Morrison et al
Physiol Rep (2016) 4 (19) DOI: 10.14814/phy2.12940
Yamada, Wondergem, Morrison et al
Physiol Rep (2016) 4 (19) DOI: 10.14814/phy2.12940
Cited by 31
AI Summary: In this paper, OriGene’s human LRRC8C cDNA (Cat# RC217651) was used to coexpress with zebrafish lrrc8aa in LRRC8(-/-) human cells, demonstrating the functional reconstitution of swelling-activated Cl- currents and confirming the essential role of LRRC8A in VRAC activity.
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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