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HTRA1 Mutant (R302A) Human Recombinant Protein

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SKU
TP701132
Purified mutant recombinant protein of Human HtrA serine peptidase 1 (HTRA1), residues 161-369aa and mutation at（R302A)
Size:
20 ug
  $900.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC222362, residues 161-369aa of htra1_cat_R302A
Tag Myc-DDK
Predicted MW 22.5 kDa
Concentration >0.05 µg/µL as determined by microplate Bradford method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002766.1
Locus ID 5654
Cytogenetics 10q26.13
RefSeq Size 2133
RefSeq ORF 1440
Synonyms ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11
Summary This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. provided by RefSeq, Jul 2008
Protein Categories Enzyme: Peptidases, Growth Factors, Intracellular Proteins, Nervous system Diseases, Secreated Proteins
Protein Families Druggable Genome, Protease, Secreted Protein
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Documents
Resources

file-alt Citations

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
Cabrera, Melo, Roth et al
Sci Rep (2017) 7 (1), 14804 DOI: 10.1038/s41598-017-14208-z
Cited by 31
AI Summary: OriGene products, specifically the HtrA1 cDNA clone (Cat# RC209307) and anti-HtrA1 antibody (Cat# TA500043), were used in this study to express and detect HtrA1 protein, enabling the authors to investigate the allosteric activation mechanism and inter-monomer communication in HtrA1 trimers.
FigureFigureFigure
Showing 1-1 of 1 papers.
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