CNTF (NM_000614) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC222331 |
| Predicted MW | 22.8 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000605 |
| RefSeq Size | 1891 |
| RefSeq ORF | 600 |
| Synonyms | HCNTF |
| Locus ID | 1270 |
| UniProt ID | P26441 |
| Cytogenetics | 11q12.1 |
| Summary | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. provided by RefSeq, Oct 2010 |
| Protein Families | Druggable Genome |
| Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CNTF" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC424606 | Lyophilized CNTF HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424606 | Transient overexpression lysate of ciliary neurotrophic factor (CNTF) (as WB positive control) | 100 ug |
$436.00
|
|
| TP322331 | Recombinant protein of human ciliary neurotrophic factor (CNTF), 20 µg | 20 ug |
$737.00
|
|
| TP720608 | Purified recombinant protein of Human ciliary neurotrophic factor (CNTF) | 10 ug |
$290.00
|
|
Citations
CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa
Lipinski, Barnard, Singh et al
Mol Ther (2015) 23 (8), 1308-1319 DOI: 10.1038/mt.2015.68
Lipinski, Barnard, Singh et al
Mol Ther (2015) 23 (8), 1308-1319 DOI: 10.1038/mt.2015.68
Cited by 74
AI Summary: In this study, OriGene’s mouse CNTF cDNA (Cat# MG216985) and mouse CNTF qPCR primer pair (Cat# MP209881) were used to facilitate gene expression analysis and validation of CNTF overexpression, supporting the investigation of CNTF’s neuroprotective effects in a mouse model of retinitis pigmentosa.
Showing 1-1 of 1 papers.
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