Caspase-7 (CASP7) (NM_001227) Human Mass Spec Standard

SKU
PH321545
CASP7 MS Standard C13 and N15-labeled recombinant protein (NP_001218)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC221545
Predicted MW 34.3 kDa
Protein Sequence
Protein Sequence
>RC221545 protein sequence
Red=Cloning site Green=Tags(s)

MADEQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKC
IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACI
LLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPR
YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDP
HFHEKKQIPCVVSMLTKELYFSQ

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_001218
RefSeq Size 2607
RefSeq ORF 909
Synonyms CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Locus ID 840
UniProt ID P55210
Cytogenetics 10q25.3
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, May 2012
Protein Families Druggable Genome, Protease
Protein Pathways Alzheimer's disease, Apoptosis
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LY429055 Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant alpha (as WB positive control) 100 ug
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LY429870 Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant delta (as WB positive control) 100 ug
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