Caspase-7 (CASP7) (NM_033339) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC202059 |
| Predicted MW | 34.3 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_203125 |
| RefSeq Size | 2681 |
| RefSeq ORF | 909 |
| Synonyms | CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3 |
| Locus ID | 840 |
| UniProt ID | P55210 |
| Cytogenetics | 10q25.3 |
| Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, May 2012 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Alzheimer's disease, Apoptosis |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Caspase-7" proteins (17)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321545 | CASP7 MS Standard C13 and N15-labeled recombinant protein (NP_001218) | 10 ug |
$3,360.00
|
|
| PH321589 | CASP7 MS Standard C13 and N15-labeled recombinant protein (NP_203124) | 10 ug |
$3,360.00
|
|
| LC409591 | Lyophilized CASP7 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC409592 | Lyophilized CASP7 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC409593 | Lyophilized CASP7 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC420060 | Lyophilized CASP7 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC429055 | Lyophilized CASP7 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC429870 | Lyophilized CASP7 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY409591 | Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant delta (as WB positive control) | 100 ug |
$436.00
|
|
| LY409592 | Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant gamma (as WB positive control) | 100 ug |
$436.00
|
|
| LY409593 | Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant beta (as WB positive control) | 100 ug |
$436.00
|
|
| LY420060 | Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant alpha (as WB positive control) | 100 ug |
$436.00
|
|
| LY429055 | Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant alpha (as WB positive control) | 100 ug |
$436.00
|
|
| LY429870 | Transient overexpression lysate of caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant delta (as WB positive control) | 100 ug |
$436.00
|
|
| TP302059 | Recombinant protein of human caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant gamma, 20 µg | 20 ug |
$737.00
|
|
| TP321545 | Recombinant protein of human caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant alpha, 20 µg | 20 ug |
$737.00
|
|
| TP321589 | Purified recombinant protein of Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant delta, 20 µg | 20 ug |
$737.00
|
|
Citations
Altered processing of amyloid precursor protein in cells undergoing apoptosis
Fiorelli, Kirouac, Padmanabhan
PLoS ONE (2013) 8 (2), e57979 DOI: 10.1371/journal.pone.0057979
Fiorelli, Kirouac, Padmanabhan
PLoS ONE (2013) 8 (2), e57979 DOI: 10.1371/journal.pone.0057979
Cited by 15
AI Summary: OriGene’s caspase-3 and caspase-7 shRNA clones were used to transiently knock down these caspases in H4-APP cells, enabling the study to demonstrate that caspase activity is required for the generation of novel amyloid precursor protein fragments during apoptosis.
Snippet: Analysis of the lysates with an antibody generated against caspase-cleaved APP detected a single band of ~25 kDa size ... Sets of four shRNA clones each to caspase-3 and caspase-7 were obtained from OriGene (Rockville, MD) and were transiently transfected into H4-APP cells
Showing 1-1 of 1 papers.
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