SHP2 (PTPN11) (NM_002834) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC220029 |
| Predicted MW | 67.8 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002825 |
| RefSeq Size | 6300 |
| RefSeq ORF | 1779 |
| Synonyms | BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 |
| Locus ID | 5781 |
| UniProt ID | Q06124 |
| Cytogenetics | 12q24.13 |
| Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. provided by RefSeq, Aug 2016 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "SHP2" proteins (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TP320029 | Recombinant protein of human protein tyrosine phosphatase, non-receptor type 11 (PTPN11), 20 µg | 20 ug |
$737.00
|
|
| TP750155 | Purified recombinant protein of PTPN11, Met1-Leu525,expressed in E. coli,50ug | 50 ug |
$270.00
|
|
| TP750156 | Purified recombinant protein of PTPN11, Met1-Leu525(mutant Glu76Lys),expressed in E. coli,50ug. | 50 ug |
$270.00
|
|
| TP750157 | Purified recombinant protein of PTPN11, Met1-Leu525(mutant Asp61Tyr),expressed in E. coli,50ug | 50 ug |
$270.00
|
|
| TP750158 | Purified recombinant protein of PTPN11, Met1-Leu525(mutant Ser502Leu),expressed in E. coli,50ug | 50 ug |
$270.00
|
|
| TP750164 | Purified recombinant protein of Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11), Ala237-Ile529, with N-terminal His tag, expressed in E.coli, 50ug | 50 ug |
$270.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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