LCK (NM_005356) Human Mass Spec Standard

SKU
PH319375
LCK MS Standard C13 and N15-labeled recombinant protein (NP_005347)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC219375
Predicted MW 57.8 kDa
Protein Sequence
Protein Sequence
RC219375
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_005347
RefSeq Size 2032
RefSeq ORF 1527
Synonyms IMD22; LSK; p56lck; pp58lck; YT16
Locus ID 3932
UniProt ID P06239
Cytogenetics 1p35.2
Summary This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. provided by RefSeq, Aug 2016
Protein Families Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway
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LY420808 Transient overexpression lysate of lymphocyte-specific protein tyrosine kinase (LCK), transcript variant 1 (as WB positive control) 100 ug
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TP319375 Recombinant protein of human lymphocyte-specific protein tyrosine kinase (LCK), transcript variant 2, 20 µg 20 ug
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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