ABAT (NM_020686) Human Mass Spec Standard
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC218980 |
| Predicted MW | 56.5 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_065737 |
| RefSeq Size | 4814 |
| RefSeq ORF | 1500 |
| Synonyms | GABA-AT; GABAT; NPD009 |
| Locus ID | 18 |
| UniProt ID | P80404 |
| Cytogenetics | 16p13.2 |
| Summary | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. provided by RefSeq, Jul 2008 |
| Protein Families | Druggable Genome |
| Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, leucine and isoleucine degradation, Metabolic pathways, Propanoate metabolism, Valine |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "ABAT" proteins (11)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH306793 | ABAT MS Standard C13 and N15-labeled recombinant protein (NP_000654) | 10 ug |
$3,360.00
|
|
| PH325860 | ABAT MS Standard C13 and N15-labeled recombinant protein (NP_001120920) | 10 ug |
$3,360.00
|
|
| LC400218 | Lyophilized ABAT HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC412383 | Lyophilized ABAT HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC426789 | Lyophilized ABAT HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400218 | Transient overexpression lysate of 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY412383 | Transient overexpression lysate of 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| LY426789 | Transient overexpression lysate of 4-aminobutyrate aminotransferase (ABAT), transcript variant 3 (as WB positive control) | 100 ug |
$436.00
|
|
| TP306793 | Recombinant protein of human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 2, 20 µg | 20 ug |
$867.00
|
|
| TP318980 | Recombinant protein of human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1, 20 µg | 20 ug |
$867.00
|
|
| TP325860 | Recombinant protein of human 4-aminobutyrate aminotransferase (ABAT), transcript variant 3, 20 µg | 20 ug |
$867.00
|
|
Citations
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