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NSMCE1 (NM_145080) Human Mass Spec Standard

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SKU
PH318073
NSMCE1 MS Standard C13 and N15-labeled recombinant protein (NP_659547)
Size:
10 ug
  $3,360.00
3 Weeks*
Bulk/Customize

Frequently Bought Together (2)

TA308558 Rabbit polyclonal antibody to NSMCE1 (non-SMC element 1 homolog (S. cerevisiae))
100 ul
$665.00
LY408050 Transient overexpression lysate of non-SMC element 1 homolog (S. cerevisiae) (NSMCE1) (as WB positive control) 100 ug
$436.00

Other products for "NSMCE1 or NM_145080"

Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC218073
Predicted MW 30.7 kDa
Protein Sequence
Protein Sequence
>RC218073 representing NM_145080
Red=Cloning site Green=Tags(s)

MQGSTRRMGVMTDVHRRFLQLLMTHGVLEEWDVKRLQTHCYKVHDRNATVDKLEDFINNINSVLESLYIE
IKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSETGFASSTNILNLVDQLKGKK
MRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYIRETYPDAVKICNICHSLLIQGQSCETCGIR
MHLPCVAKYFQSNAEPRCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSRQH

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_659547
RefSeq Size 1079
RefSeq ORF 798
Synonyms NSE1
Locus ID 197370
UniProt ID Q8WV22
Cytogenetics 16p12.1
Summary RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034).UniProtKB/Swiss-Prot Function
Protein Families Druggable Genome
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Other "NSMCE1" proteins (3)
SKU Description Size Price
LC408050 Lyophilized NSMCE1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY408050 Transient overexpression lysate of non-SMC element 1 homolog (S. cerevisiae) (NSMCE1) (as WB positive control) 100 ug
$436.00
TP318073 Recombinant protein of human non-SMC element 1 homolog (S. cerevisiae) (NSMCE1), 20 µg 20 ug
$867.00

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