DNMT3A (NM_022552) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC213064 |
| Predicted MW | 101.9 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_072046 |
| RefSeq Size | 4324 |
| RefSeq ORF | 2736 |
| Synonyms | DNMT3A2; HESJAS; M.HsaIIIA; TBRS |
| Locus ID | 1788 |
| UniProt ID | Q9Y6K1 |
| Cytogenetics | 2p23.3 |
| Summary | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. provided by RefSeq, Mar 2016 |
| Protein Families | Druggable Genome |
| Protein Pathways | Cysteine and methionine metabolism, Metabolic pathways |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "DNMT3A" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC411621 | Lyophilized DNMT3A HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY411621 | Transient overexpression lysate of DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A), transcript variant 3 (as WB positive control) | 100 ug |
$665.00
|
|
| TP313064 | Recombinant protein of human DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A), transcript variant 3, 20 µg | 20 ug |
$737.00
|
|
Citations
PML-RARA requires DNA methytransferase 3A to initiate acute promyelocytic leukemia
Cole, Verdoni, Ketkar et al
J. Clin. Invest. (2015)
Cole, Verdoni, Ketkar et al
J. Clin. Invest. (2015)
AI Summary: OriGene products contributed full-length human DNMT3A (NM_175629) and DNMT3B (NM_006892) cDNAs, which were used to study the functional roles of these enzymes in leukemia initiation in this paper.
Snippet: Full-length human DNMT3A (NM_175629) and DNMT3B (NM_006892) cDNAs (Origene) were cloned into MSCV- IRES-YFP or MSCV IRES-GFP (Addgene) using PCR-introduced EcoRI restriction digest sites and standard ligation techniques. DNMT3A R882H and Q615* mutations were introduced using a QuikChange II XL mutagenesis kit (Agilent Technologies)
Showing 1-1 of 1 papers.
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