COP (CARD16) (NM_052889) Human Mass Spec Standard

SKU
PH311537
CARD16 MS Standard C13 and N15-labeled recombinant protein (NP_443121)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC211537
Predicted MW 10.6 kDa
Protein Sequence
Protein Sequence
>RC211537 representing NM_052889
Red=Cloning site Green=Tags(s)

MRKAMADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGA
QACQICITYICEEDSYLAETLGLSAGPIPGN

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_443121
RefSeq Size 758
RefSeq ORF 303
Synonyms COP; COP1; PSEUDO-ICE
Locus ID 114769
UniProt ID Q5EG05
Cytogenetics 11q22.3
Summary Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.UniProtKB/Swiss-Prot Function
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Other "COP" proteins (6)
SKU Description Size Price
LC409399 Lyophilized CARD16 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC422744 Lyophilized CARD16 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY409399 Transient overexpression lysate of caspase recruitment domain family, member 16 (CARD16), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY422744 Transient overexpression lysate of caspase recruitment domain family, member 16 (CARD16), transcript variant 1 (as WB positive control) 100 ug
$436.00
TP311537 Recombinant protein of human caspase recruitment domain family, member 16 (CARD16), transcript variant 2, 20 µg 20 ug
$867.00
TP760353 Purified recombinant protein of Human caspase recruitment domain family, member 16 (CARD16), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug 50 ug
$270.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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