TAB1 (NM_006116) Human Mass Spec Standard

CAT#: PH308522

TAB1 MS Standard C13 and N15-labeled recombinant protein (NP_006107)

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USD 1,995


Availability*
3 Weeks

Size
    • 10 ug

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Specifications

Product Data
Description TAB1 MS Standard C13 and N15-labeled recombinant protein (NP_006107)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208522
Predicted MW 54.5 kDa
Protein Sequence
Tag C-MYC/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_006107
RefSeq Size 3240
RefSeq ORF 1512
Synonyms 3 -Tab1; MAP3K7IP1; 3'-Tab1
Locus ID 10454
Cytogenetics 22q13.1
Summary The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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