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AIF (AIFM1) (NM_004208) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC224064L1V
Lenti ORF particles, AIFM1 (Myc-DDK tagged) - Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1, 200ul, >10^7 TU/mL
  $1,121.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol AIF
Synonyms AIF; AUNX1; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8; SEMDHL
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC224064).
ACCN NM_004208
ORF Size 1839 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_004208.2
RefSeq Size 2215 bp
RefSeq ORF 1842 bp
Locus ID 9131
UniProt ID O95831
Cytogenetics Xq26.1
Domains pyr_redox
Protein Families Druggable Genome, Transmembrane
Protein Pathways Apoptosis
MW 66.7 kDa
Summary This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. provided by RefSeq, Aug 2015
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Documents
Resources

file-alt Citations

[PROVISIONAL] Whole exome sequencing identifies a novel variant in an apoptosis-inducing factor gene associated with X-linked recessive hearing loss in a Chinese Family
Wang, Lu, Ding et al
Genet. Mol. Biol. (2019)
AI Summary: OriGene contributed a mammalian expression plasmid containing the human AIFM1 cDNA with a green fluorescent protein (GFP) tag, which was used to study the apoptosis effects of the identified AIFM1 variant in cell experiments.
Snippet: … A mammalian expression plasmid containing an open reading frame of human AIFM1 cDNA with a green fluorescent protein (GFP) tag at the 3' end was obtained from Origene (Rockville, MD, USA) Cached;Apoptosis effects of the candidate variants A mammalian expression plasmid containing an open reading frame of human AIFM1 cDNA with a green fluorescent protein (GFP) tag at the 3ʹ end was obtained from Origene (Rockville, MD, USA) View as HTML
Showing 1-1 of 1 papers.
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