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Proprotein Convertase 2 (PCSK2) (NM_002594) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC222498L2V
Lenti ORF particles, PCSK2 (mGFP-tagged) - Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1, 200ul, >10^7 TU/mL
  $1,144.00
5 Weeks*
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Other products for "Proprotein Convertase 2 or NM_002594"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol Proprotein Convertase 2
Synonyms NEC-2; NEC 2; NEC2; PC2; SPC2
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC222498).
ACCN NM_002594
ORF Size 1914 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_002594.2
RefSeq Size 4745 bp
RefSeq ORF 1917 bp
Locus ID 5126
UniProt ID P16519
Cytogenetics 20p12.1
Domains P, Peptidase_S8
Protein Families Druggable Genome, Protease, Secreted Protein
MW 70.57 kDa
Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, Jan 2014
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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