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IDE (NM_004969) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC220700L2V
Lenti ORF particles, IDE (mGFP-tagged) - Human insulin-degrading enzyme (IDE), transcript variant 1, 200ul, >10^7 TU/mL
  $1,437.00
5 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol IDE
Synonyms INSULYSIN
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC220700).
ACCN NM_004969
ORF Size 3057 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_004969.1, NP_004960.1
RefSeq Size 3279 bp
RefSeq ORF 3060 bp
Locus ID 3416
UniProt ID P14735
Cytogenetics 10q23.33
Domains Peptidase_M16, Peptidase_M16_C
Protein Families Druggable Genome, Protease
Protein Pathways Alzheimer's disease
MW 117.8 kDa
Summary This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.provided by RefSeq, Sep 2009
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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