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TRPM2 (NM_003307) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC216220L3V
Lenti ORF particles, TRPM2 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1, 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK w/ Puro mGFP w/ Puro
  $1,836.00
5 Weeks*
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Other products for "TRPM2 or NM_003307"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol TRPM2
Synonyms EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; TRPC7
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC216220).
ACCN NM_003307
ORF Size 4509 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_003307.3, NP_003298.1
RefSeq Size 5876 bp
RefSeq ORF 4512 bp
Locus ID 7226
UniProt ID O94759
Cytogenetics 21q22.3
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
MW 171.7 kDa
Summary The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. provided by RefSeq, Feb 2016
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Documents
Resources

file-alt Citations

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate
Csanády, Törocsik
J Gen Physiol (2009) 133 (2), 189-203 DOI: 10.1085/jgp.200810109
Cited by 103
AI Summary: In this paper, OriGene’s human TRPM2 cDNA (OriGene, SC118291) was used to express the TRPM2 channel in Xenopus oocytes, enabling the functional studies that elucidated the Ca2+ activation mechanism of TRPM2.
FigureFigureFigure
Showing 1-1 of 1 papers.
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