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MEKK1 (MAP3K1) (NM_005921) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC214358L1V
Lenti ORF particles, MAP3K1 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 1 (MAP3K1), 200ul, >10^7 TU/mL
  $2,490.00
5 Weeks*
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Other products for "MEKK1 or NM_005921"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol MEKK1
Synonyms MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC214358).
ACCN NM_005921
ORF Size 4536 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_005921.1
RefSeq Size 7522 bp
RefSeq ORF 4539 bp
Locus ID 4214
UniProt ID Q13233
Cytogenetics 5q11.2
Protein Families Druggable Genome, Protein Kinase
Protein Pathways GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, RIG-I-like receptor signaling pathway, Ubiquitin mediated proteolysis
MW 164.3 kDa
Summary The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. provided by RefSeq, Mar 2012
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Documents
Resources

file-alt Citations

MAP2K1 and MAP3K1 mutations in langerhans cell histiocytosis
Nelson, van Halteren, Quispel et al
Genes Chromosomes Cancer (2015) 54 (6), 361-8 DOI: 10.1002/gcc.22247
Cited by 202
AI Summary: OriGene products contributed to this study by providing C-terminal DDK (FLAG)-tagged human MAP2K1 (catalog number RC218460) and MAP3K1 (catalog number RC214358) expression vectors, which were used as templates for generating mutant constructs to assess their functional effects in vitro.
Snippet: Vectors expressing C-terminal DDK- (FLAG-) tagged human MAP2K1 and MAP3K1 (purchased from Origene Technologies, Bethesda MD, catalog numbers RC218460 and RC214358, respectively) were used as templates for two-step PCR mutagenesis by primer ... Cite SaveSaving
Showing 1-1 of 1 papers.
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