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ADAMTS8 (NM_007037) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC212446L4V
Lenti ORF particles, ADAMTS8 (mGFP-tagged) - Human ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ADAMTS8), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
mGFP w/ Puro DDK w/ Puro
  $1,363.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol ADAMTS8
Synonyms ADAM-TS8; METH2
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC212446).
ACCN NM_007037
ORF Size 2664 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_007037.3
RefSeq Size 4028 bp
RefSeq ORF 2670 bp
Locus ID 11095
UniProt ID Q9UP79
Cytogenetics 11q24.3
Protein Families Druggable Genome, Protease, Secreted Protein
MW 96.3 kDa
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. provided by RefSeq, Feb 2016
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Documents
Resources

file-alt Citations

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts
Badshah, Brown, Weibel et al
Br. J. Dermatol. (2018)
AI Summary: OriGene's ADAMTS8 (NM_007037) Human LentiORF Particles and LentiORF Control Particles (pLenti-C-mGFP-P2A-Puro) were used to stably transduce fibroblasts for overexpression and control experiments, enabling the study of ADAMTS8's role in pro-fibrotic changes in linear morphoea fibroblasts.
Snippet: Linear morphoea normal primary dermal fibroblasts were stably transduced with: ADAMTS8 (NM_007037) Human LentiORF Particles (pLenti-C-mGFP-P2A-Puro;OriGene) for overexpression, or LentiORF Control Particles (pLenti-C-mGFP-P2A-Puro;OriGene) as an
Showing 1-1 of 1 papers.
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