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Serotonin transporter (SLC6A4) (NM_001045) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC210187L1V
Lenti ORF particles, SLC6A4 (Myc-DDK tagged) - Human solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), 200ul, >10^7 TU/mL
  $1,429.00
3 Weeks*
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Other products for "Serotonin transporter or NM_001045"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol Serotonin transporter
Synonyms 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC210187).
ACCN NM_001045
ORF Size 1890 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_001045.2
RefSeq Size 2756 bp
RefSeq ORF 1893 bp
Locus ID 6532
UniProt ID P31645
Cytogenetics 17q11.2
Domains 5HT_transporter, SNF
Protein Families Druggable Genome, Transmembrane
MW 70.1 kDa
Summary This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. provided by RefSeq, May 2019
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Documents
Resources

file-alt Citations

"Ecstasy" to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA
Dolan, Chen, Huang et al
Neuropharmacology (2018) 133, 171-180 DOI: 10.1016/j.neuropharm.2018.01.020
AI Summary: OriGene’s GFP-tagged human serotonin-transporter cDNA (hSERT, Cat# MG227448) was used to transiently transfect cells for electrophysiological studies assessing the action of synthetic cathinones at the serotonin transporter in this paper.
Snippet: Cells were transiently transfected using PolyJet transfection reagent (SignaGen, Rockville, MD) with 0.5 μg GFP-tagged human serotonin-transporter cDNA (hSERT, Cat# MG227448, Origene Technologies, Rockville, MD)
Showing 1-1 of 1 papers.
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