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PAPP A (PAPPA) (NM_002581) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC209767L1V
Lenti ORF particles, PAPPA (Myc-DDK-tagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA), 200ul, >10^7 TU/mL
  $2,637.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol PAPP A
Synonyms ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC209767).
ACCN NM_002581
ORF Size 4881 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_002581.3
RefSeq Size 11025 bp
RefSeq ORF 4884 bp
Locus ID 5069
UniProt ID Q13219
Cytogenetics 9q33.1
Protein Families Druggable Genome, Protease, Secreted Protein
MW 181.4 kDa
Summary This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. provided by RefSeq, Aug 2017
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Documents
Resources

file-alt Citations

Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer
Loddo, Andryszkiewicz, Rodriguez-Acebes et al
J. Pathol. (2014)
Cited by 34
AI Summary: OriGene products contributed to this study by providing three 27mer RNA duplexes for FOXM1 knockdown (OriGene SR301615) and full-length human PAPPA and ZMPSTE24 cDNA clones in pCMV6-XL5 vectors, which were used to manipulate gene expression and investigate their roles in mitosis and breast cancer.
Snippet: custom RNA duplexes (Thermo Scientific) and FOXM1 with three 27mer RNA duplexes (Origene SR301615). ... Full-length human PAPPA cDNA (NM_002581.3) and ZMPSTE24 cDNA (NM_005857.2) were cloned into pCMV6-XL5 vectors (OriGene). Approximately 2x106 ... Cite SaveSaving
Showing 1-1 of 1 papers.
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