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SGPL1 (NM_003901) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC208705L2V
Lenti ORF particles, SGPL1 (mGFP-tagged) - Human sphingosine-1-phosphate lyase 1 (SGPL1), 200ul, >10^7 TU/mL
  $1,079.00
5 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol SGPL1
Synonyms NPHS14; S1PL; SPL
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC208705).
ACCN NM_003901
ORF Size 1704 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_003901.2, NP_003892.2
RefSeq Size 4701 bp
RefSeq ORF 1707 bp
Locus ID 8879
UniProt ID O95470
Cytogenetics 10q22.1
Domains pyridoxal_deC
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Sphingolipid metabolism
MW 63.3 kDa
Summary Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).UniProtKB/Swiss-Prot Function
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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