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Gramd1b (BC070451) Mouse Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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MR210355L2V
Lenti ORF particles, Gramd1b (GFP-tagged) - Mouse GRAM domain containing 1B (cDNA clone MGC:99432 IMAGE:30616509), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
mGFP DDK
  $1,222.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol Gramd1b
Synonyms KIAA1201, mKIAA1201, 3222402H23
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR210355).
ACCN BC070451
ORF Size 2202 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq BC070451, AAH70451
RefSeq Size 7363 bp
RefSeq ORF 2204 bp
Locus ID 235283
Cytogenetics 9 A5.1
Summary Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461).UniProtKB/Swiss-Prot Function
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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