MARK2 (NM_017490) Human Untagged Clone
SKU
SC323417
MARK2 (untagged)-Kinase deficient mutant (K49M) of Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1
$683.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | MARK2 |
| Synonyms | EMK-1; EMK1; PAR-1; Par-1b; Par1b |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_017490 |
| Insert Size | 2700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_017490.1, NP_059672.1 |
| RefSeq Size | 2946 bp |
| RefSeq ORF | 2238 bp |
| Locus ID | 2011 |
| UniProt ID | Q7KZI7 |
| Cytogenetics | 11q13.1 |
| Domains | KA1, pkinase, UBA |
| Protein Families | Druggable Genome, Protein Kinase |
| Summary | This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2009 Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_017490" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC213764 | MARK2 (Myc-DDK-tagged)-Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1 | 10 ug |
$682.00
|
|
| RC213764L1 | Lenti ORF clone of Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$982.00
|
|
| RC213764L2 | Lenti ORF clone of Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, mGFP tagged | 10 ug |
$982.00
|
|
| RC213764L3 | Lenti ORF clone of Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$982.00
|
|
| RC213764L4 | Lenti ORF clone of Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, mGFP tagged | 10 ug |
$982.00
|
|
| RG213764 | MARK2 (tGFP-tagged) - Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1 | 10 ug |
$789.00
$882.00
|
|
| SC114124 | MARK2 (untagged)-Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1 | 10 ug |
$683.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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