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Dematin (DMTN) (NM_001978) Human Untagged Clone

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SKU
SC320164
EPB49 (untagged)-Human erythrocyte membrane protein band 4.9 (dematin) (EPB49), transcript variant 1
  $457.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol Dematin
Synonyms DMT; EPB49
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_001978.1 GTTGCCTGGTTGTGAGAGTCAGGGGAGCAGGGACAGGTCCAAGACAAGGAAGGCAGTTGG
GCTGTGGGAATGGGGAGCCCAGGGAAGGCCTCCAGAGCTGGCCTGGAGAGTCACCGCCGA
GGGATGAGGACGCGCCAGCCCGGGGGAACGCGCCAGCTGCTTTCGCGGCCCCAAGCGCGC
AGTGCCCAGCAGCCGCGCCGAGCCTGACACGCTGTCCTCTCCCCTCGCGCACAGGGCTCT
GCGAGTGACCCGGCGGGCGAGCTCCGTGCTGCATGGAACGGCTGCAGAAGCAACCACTTA
CCTCCCCCGGGAGCGTGAGCCCCTCCCGAGATTCCAGTGTGCCTGGCTCTCCCTCCAGCA
TCGTGGCCAAGATGGACAATCAGGTGCTGGGCTACAAGGACCTGGCTGCCATCCCCAAGG
ACAAGGCCATCCTGGACATCGAGCGGCCCGACCTCATGATCTACGAGCCTCACTTCACTT
ATTCCCTCCTGGAACACGTGGAGCTGCCTCGCAGCCGCGAGCGCTCGCTGTCACCCAAAT
CCACATCCCCCCCACCATCCCCAGAGGTGTGGGCGGACAGCCGGTCGCCTGGAATCATCT
CTCAGGCCTCGGCCCCCAGAACCACTGGAACCCCCCGGACCAGCCTGCCCCATTTCCACC
ACCCTGAGACCTCCCGCCCAGATTCCAACATCTACAAGAAGCCTCCCATCTATAAGCAGA
GAGAGTCCGTGGGAGGCAGCCCTCAGACCAAGCACCTCATCGAGGATCTCATCATCGAGT
CATCCAAGTTTCCTGCAGCCCAGCCCCCAGACCCCAACCAGCCAGCCAAAATCGAAACCG
ACTACTGGCCATGCCCCCCGTCTCTGGCTGTTGTGGAGACAGAATGGAGGAAGCGGAAGG
CGTCTCGGAGGGGAGCAGAGGAAGAGGAGGAGGAGGAAGATGACGACTCTGGAGAGGAGA
TGAAGGCTCTCAGGGAGCGTCAGAGAGAGGAACTCAGTAAGGTTACTTCCAACTTGGGAA
AGATGATCTTGAAAGAAGAGATGGAAAAGTCATTGCCGATCCGAAGGAAAACCCGCTCTC
TGCCTGACCGGACACCCTTCCATACCTCCTTGCACCAGGGAACGTCTAAATCTTCCTCTC
TCCCCGCCTATGGCAGGACCACCCTGAGCCGGCTACAGTCCACAGAGTTCAGCCCATCAG
GGAGTGAGACTGGAAGCCCAGGCCTGCAGAACGGAGAGGGCCAGAGGGGGAGGATGGACC
GGGGGAACTCCCTGCCCTGTGTGCTGGAGCAGAAGATCTATCCCTATGAAATGCTAGTGG
TGACCAACAAGGGGCGAACCAAGCTGCCACCGGGGGTGGATCGGATGCGGCTTGAGAGGC
ATCTGTCTGCCGAGGACTTCTCAAGGGTATTTGCCATGTCCCCTGAAGAGTTTGGCAAGC
TGGCTCTGTGGAAGCGGAATGAGCTCAAGAAGAAGGCCTCTCTCTTCTGATGGCCCCCAC
CTGCTCCGGGACGGCCCCCTTACCCCTGCTGCTTCAGGGTTTTTCCCCGGCGGGTTGGGA
GGGGCAGGAGGTGGGGTGGAAATAGGGTGGGCTCCTTTCCTCAGGTAGAGTGGGGGGCCA
AAACCTCTGCAGTCCCCGGCAGTGAGCTATGGACTTTCTTCCCCCTCACAAGGCTGGGGG
CCTCCTGCTCTCGTCCCTGGCCCTCCCTGCACAGGGCAAAGCCAGTCTGGGCTCTGGCAC
ACAGAGTTCATGTTTGCGCCCTCTCCCTGCCCCTCACCCCAGAGGGTGAGGAGGAATGAG
GGGCATTGGTGGTTAGGCCGGTTGGCTGTCTTGAACAGCTGGAGGGAAGATGCAGGGGTG
GGAAGCGGCCAGGCAGAAAGAGCTCCAGGCTCTTGTGTCGCCCACCCAGCCCTCCCATAC
TCACTCCTGACAGCTTTCCTGCACTGCAGCTTCCTGCTCCTCTGACTCTAGTGGGAACAG
GCCCCAGCTCAGCCTCCGGCAGGGAGGTCACCCCTCCACTTCAGCTTGCCCTGACCTCCG
CTCGCAAACCCCGAGCTTCCAAGCCTTTTGCTCCAGCCCTGCGGCTTCCCCAGAAGCCTG
GGCTTAGGGTGGAGATGCCGCCTACACACGATCCTGGCCCTCCACCTGCCTCCAGGCCAC
GAAATGGGAATTCCAGCACTAAGCCAGGCACCGGGCAGAAGCTGGGCCTTCCGCCTCCCT
TGGATGGGGTCAAGAGGCCAGGCCTGGCACATTTTGGAGTGTCCTGGCTACCAGCTCTCA
CCTACACCCACGCACCCCCCCACACACTATGCTCTCTCAAGAATGTAATTTATTGGGGCC
CCCCCCAGCTGCTTTCCTCACCTGCCCCTGCCCTACCTTACACCCCCAGCTTGACTTCTT
TCCAGTCCACGTGTGTATATAATGATATCTATATTTTTGCCCAGGTCTGGGTATTGCTCC
TGCCCAGACCCTGACATCCCTTTCCACTGTGTGTGTGACCATGCTGGGGGAGGGGGACTC
TGCTTGGAATTAAAAGGTTGCATTGGGTCCCTAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA
Restriction Sites Please inquire |
ACCN NM_001978
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001978.1, NP_001969.1
RefSeq Size 2727 bp
RefSeq ORF 1218 bp
Locus ID 2039
UniProt ID Q08495
Cytogenetics 8p21.3
Domains VHP
Summary The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Nov 2014
Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-3 and 9-13 all encode the same isoform (1, also known as the 52 kDa subunit, PMID:7615546).
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Documents
Resources
"NM_001978" in other vectors (4)
SKU Description Size Price
RC202895 EPB49 (Myc-DDK-tagged)-Human erythrocyte membrane protein band 4.9 (dematin) (EPB49), transcript variant 1 10 ug
$457.00
RC202895L3 Lenti ORF clone of Human erythrocyte membrane protein band 4.9 (dematin) (EPB49), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC202895L4 Lenti ORF clone of Human erythrocyte membrane protein band 4.9 (dematin) (EPB49), transcript variant 1, mGFP tagged 10 ug
$757.00
RG202895 EPB49 (tGFP-tagged) - Human erythrocyte membrane protein band 4.9 (dematin) (EPB49), transcript variant 1 10 ug
$489.00 $657.00

file-alt Citations

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