GDAP1 (NM_018972) Human Untagged Clone
SKU
SC317569
GDAP1 (untagged)-Human ganglioside-induced differentiation-associated protein 1 (GDAP1), transcript variant 1
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | GDAP1 |
| Synonyms | CMT4; CMT4A; CMTRIA |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_018972 |
| Insert Size | 3700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_018972.2, NP_061845.2 |
| RefSeq Size | 3899 bp |
| RefSeq ORF | 1077 bp |
| Locus ID | 54332 |
| UniProt ID | Q8TB36 |
| Cytogenetics | 8q21.11 |
| Domains | GST_N |
| Protein Families | Druggable Genome, Transmembrane |
| Summary | This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene. provided by RefSeq, Feb 2012 Transcript Variant: This variant (1) represents the longest variant and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_018972" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC216781 | GDAP1 (Myc-DDK-tagged)-Human ganglioside-induced differentiation-associated protein 1 (GDAP1), transcript variant 1 | 10 ug |
$686.00
|
|
| RC216781L3 | Lenti ORF clone of Human ganglioside-induced differentiation-associated protein 1 (GDAP1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC216781L4 | Lenti ORF clone of Human ganglioside-induced differentiation-associated protein 1 (GDAP1), transcript variant 1, mGFP tagged | 10 ug |
$986.00
|
|
| RG216781 | GDAP1 (tGFP-tagged) - Human ganglioside-induced differentiation-associated protein 1 (GDAP1), transcript variant 1 | 10 ug |
$886.00
|
|
Citations
Mutations in GDAP1 Influence Structure and Function of the Trans-Golgi Network
Binięda, Rzepnikowska, Kolakowski et al
Int J Mol Sci (2021) 22 (2) DOI: 10.3390/ijms22020914
Binięda, Rzepnikowska, Kolakowski et al
Int J Mol Sci (2021) 22 (2) DOI: 10.3390/ijms22020914
Cited by 16
AI Summary: OriGene’s pCMV6-XL5 GDAP1 (NM_018972) Human Untagged Clone was used as the source of GDAP1 cDNA for generating expression constructs to study the effects of GDAP1 mutations on Golgi structure and function in this research.
Snippet: silencing by Western blot. 4.3. Plasmids and DNA Manipulations The plasmids used in this study are listed in Table 1. GDAP1 cDNA was subcloned from pCMV6-XL5 GDAP1 (NM_018972) Human Untagged Clone (OriGene Technologies Inc., Rockville, MD, USA) to pIRES2-AcGFP1 Vector (TAKARA Bio, Shiga, Japan) using SacI and SalI enzymes (Thermo Fisher Scientific). Mutagenesis for mutations in the GDAP1 gene (
Pathogenic Effect of GDAP1 Gene Mutations in a Yeast Model
Rzepnikowska, Kaminska, Kabzińska et al
Genes (Basel) (2020) 11 (3) DOI: 10.3390/genes11030310
Rzepnikowska, Kaminska, Kabzińska et al
Genes (Basel) (2020) 11 (3) DOI: 10.3390/genes11030310
Cited by 16
Showing 1-2 of 2 papers.
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