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HSF4 (NM_001040667) Human Untagged Clone

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SKU
SC311161
HSF4 (untagged)-Human heat shock transcription factor 4 (HSF4), transcript variant 2
  $457.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol HSF4
Synonyms CTM; CTRCT5
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_001040667 edited
GCCCGCAGCGGCCGGGCCCGAGCGCAGAGCCGGGCCGAGACTGCACCATGCAGGAAGCGC
CAGCTGCGCTGCCCACGGAGCCAGGCCCCAGCCCCGTGCCTGCCTTCCTCGGCAAGCTAT
GGGCGCTGGTGGGGGACCCAGGCACAGACCACCTGATCCGCTGGAGCCCGAGCGGGACCA
GTTTCCTCGTAAGCGACCAGAGCCGTTTCGCCAAGGAAGTGCTGCCCCAGTATTTCAAGC
ATAGCAACATGGCGAGCTTCGTGCGCCAACTCAACATGTACGGTTTTCGGAAGGTGGTGA
GCATCGAGCAGGGCGGCCTGCTTAGGCCGGAGCGCGACCACGTCGAGTTCCAGCACCCGA
GCTTCGTGCGCGGCCGCGAGCAGCTACTGGAGCGCGTGCGGCGCAAGGTGCCCGCGCTGC
GCGGCGACGACGGCCGCTGGCGCCCGGAGGACCTGGGTCGACTACTGGGCGAGGTGCAGG
CTTTGCGGGGAGTGCAGGAGAGCACCGAGGCGCGGCTGCGGGAGCTCAGGCAGCAGAACG
AGATCTTGTGGCGGGAGGTGGTGACACTTCGGCAGAGCCACGGTCAGCAGCACCGGGTCA
TTGGCAAGCTGATCCAGTGTCTCTTTGGGCCACTTCAGGCGGGGCCGAGCAATGCAGGAG
GCAAGAGAAAGCTGTCCCTGATGCTGGATGAGGGGAGCTCATGCCCAACACCTGCCAAGT
TCAACACCTGCCCTCTACCTGGTGCCCTTCTGCAGGACCCCTACTTCATCCAGTCGCCTC
TCCCAGAGACAAATTTGGGCCTTAGCCCTCACAGGGCCAGGGGCCCCATCATCTCTGACA
TCCCAGAAGACTCTCCATCCCCTGAGGGGACCAGGCTTTCTCCCTCCAGTGATGGCAGGA
GGGAGAAGGGCCTGGCACTGCTCAAAGAAGAGCCGGCCAGTCCAGGGGGGGATGGCGAGG
CCGGGCTGGCCCTGGCCCCAAACGAGTGTGACTTCTGCGTGACAGCCCCCCCGCCACTGC
CTGTGGCTGTGGTGCAGGCCATCCTGGAAGGGAAAGGGAGCTTCAGCCCCGAGGGGCCCA
GGAATGCCCAACAGCCTGAACCAGGGGATCCCAGGGAGATACCTGACAGGGGGCCTCTGG
GCCTGGAAAGCGGGGACAGGAGCCCAGAGAGTCTGCTGCCTCCGATGCTGCTTCAGCCCC
CTCAAGAAAGTGTGGAACCTGCAGGGCCTCTAGATGTGCTGGGCCCCAGTCTCCAAGGGC
GAGAATGGACCCTGATGGACTTGGACATGGAGCTGTCCTTGATGCAGCCCTTGGTTCCAG
AGCGGGGTGAGCCTGAGCTGGCGGTCAAGGTGTTAAATTCTCCAAGCCCAGGGAAGGACC
CCACGCTCGGGGCCCCACTCCTGCTGGATGTCCAGGCGGCCTTGGGAGGCCCAGCCCTGG
GCCTGCCTGGGGCTTTAACCATTTATAGCACTCCTGAGAGCCGGACTGCCTCCTACTTGG
GCCCGGAAGCCAGTCCCTCCCCCTAAGACCCCGCGCCTCTGAAGGGGCTTGGAACCAGTC
CGCCGCTGCACATCCTTCTTGGCTTCCTGGCGCCCCCTATCGGGGGTGAGCGAAGCCCCC
ACTACTAAATGGCCTCTCTCCACTACCCCGACTATCCCTGCACATAAACTCCG
5' Read Nucleotide Sequence
>OriGene 5' read for NM_001040667 unedited
NGGGTTAGATATTTGTATACGACTCACTATAGGCGGCCGCGCAATTCGGCACGAGGGCCC
GCAGCGGCCGGGCCCGAGCGCAGAGCCGGGCCGAGACTGCACCATGCAGGAAGCGCCAGC
TGCGCTGCCCACGGAGCCAGGCCCCAGCCCCGTGCCTGCCTTCCTCGGCAAGCTATGGGC
GCTGGTGGGGGACCCAGGCACAGACCACCTGATCCGCTGGAGCCCGAGCGGGACCAGTTT
CCTCGTAAGCGACCAGAGCCGTTTCGCCAAGGAAGTGCTGCCCCAGTATTTCAAGCATAG
CAACATGGCGAGCTTCGTGCGCCAACTCAACATGTACGGTTTTCGGAAGGTGGTGAGCAT
CGAGCAGGGCGGCCTGCTTAGGCCGGAGCGCGACCACGTCGAGTTCCAGCACCCGAGCTT
CGTGCGCGGCCGCGAGCAGCTACTGGAGCGCGTGCGGCGCAAGGTGCCCGCGCTGCGCGG
CGACGACGGCCGCTGGCGCCCGGAGGACCTGGGTCGACTACTGGGCGAGGTGCAGGCTTT
GCGGGGAGTGCAGGAGAGCACCGAGGCGCGGCTGCGGGAGCTCAGGCAGCAGAACGAGAT
CTTGTGGCGGGAGGTGGTGACACTTCGGCAGAGCCACGGTCAGCAGCACCGGGTCATTGG
CAAGCTGATCCAGTGTCTCTTTGGGCCACTTCAGGCGGNGCCGAGCAATGCAGGAGGCAA
GAGAAAGCTGTCCCTGATGCTGGATGAGGGGAGCTCATGCCCAACACCTGCCAAGTTCAA
CACCTGCCCTCTACCTGGTGCCCCTCTGCNAGACCCCTACTTCATCCAGTCGCCTCTCCC
AGAGACAAATTTGGGGCCTAGCCCTCACAGGGCCCAGGGCCCCATCATCTCT
3' Read Nucleotide Sequence
>Forward primer walk for NM_001040667 unedited
ATCTTTGGGAGTCANAAGAGGGGCCCCTGGCCCTGTGAGGCTAAGGCCCAAATTGTCTCT
GGGAGAGGCGACTGGATGAAGTAGGGGTCCTGCAGAAGGGCACCAGGTAGAGGGCAGGTG
TTGAACTTGGCAGGTGTTGGGCATGAGCTCCCCTCATCCAGCATCAGGGACAGCTTTCTC
TTGCCTCCTGCATTGCTCGGCCCCGCCTGAAGTGGCCCAAAGAGACACTGGATCAGCTTG
CCAATGACCCGGTGCTGCTGACCGTGGCTCTGCCGAAGTGTCACCACCTCCCGCCACAAG
ATCTCGTTCTGCTGCCTGAGCTCCCGCAGCCGCGCCTCGGTGCTCTCCTGCACTCCCCGC
AAAGCCTGCACCTCGCCCAGTAGTCGACCCAGGTCCTCCGGGCGCCAGCGGCCGTCGTCG
CCGCGCAGCGCGGGCACCTTGCGCCGCACGCGCTCCAGTAGCTGCTCGCGGCCGCGCACG
AAGCTCGGGTGCTGGAACTCGACGTGGTCGCGCTCCGGCCTAAGCAGGCCGCCCTGCTCG
ATGCTCACCACCTTCCGAAAACCGTACATGTTGAGTTGGCGCACGAAGCTCGCCATGTTG
CTATGCTTGAAATACTGGGGCAGCACTTCCTTGGCGAAACGGCTCTGGTCGCTTACGAGG
AAACTGGTCCCGCTNCGGCTCCAGCGGATCAGGTGGTCTGTGCCTGGGTCCCCCACCAGC
GCCCATAGCTTTGCGAGGAAGGCANGCACNGNGCTGGGGCCTGGCTCCGTGGGCAGCGCA
GCTGGCGCTTCCTGCATGGTGCAGTCTCGGGCCCGCTCTGCGCTCGGGCCCCGCCGCTGC
GGGCCCTCG
Restriction Sites Please inquire |
ACCN NM_001040667
Insert Size 1700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 1 amino acids.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001040667.1, NP_001035757.1
RefSeq Size 2535 bp
RefSeq ORF 1479 bp
Locus ID 3299
UniProt ID Q9ULV5
Cytogenetics 16q22.1
Protein Families Druggable Genome, Transcription Factors
Summary Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. provided by RefSeq, Jul 2008
Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform b). This variant, alternatively referred to as HSF4b, functions as a transcriptional activator of the constitutive expression of heat shock genes. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
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Documents
Resources
"NM_001040667" in other vectors (6)
SKU Description Size Price
RC219247 HSF4 (Myc-DDK-tagged)-Human heat shock transcription factor 4 (HSF4), transcript variant 2 10 ug
$457.00
RC219247L1 Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, Myc-DDK-tagged 10 ug
$757.00
RC219247L2 Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, mGFP tagged 10 ug
$757.00
RC219247L3 Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, Myc-DDK-tagged 10 ug
$757.00
RC219247L4 Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, mGFP tagged 10 ug
$757.00
RG219247 HSF4 (tGFP-tagged) - Human heat shock transcription factor 4 (HSF4), transcript variant 2 10 ug
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file-alt Citations

Autosomal recessive congenital cataracts linked to HSF4 in a consanguineous Pakistani family
Jiao, Khan, Kaul et al
PLoS ONE (2019) 14 (12), e0225010 DOI: 10.1371/journal.pone.0225010
Cited by 5
AI Summary: OriGene’s pCMV6-XL4 vector containing wild-type HSF4b cDNA was used to generate wild-type and mutant HSF4 plasmids for functional studies in this paper.
Snippet: The wild-type and mutant HSF4 plasmids were generated as described previously.[33] Briefly, wild-type HSF4b cDNA in pCMV6-XL4 vector (OriGene Technologies, Inc.) was digested with EcoRI and SmaI and cloned into the pFLAG-CMV-5 vector (Sigma-Aldrich
FigureFigureFigure
Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation
He, Limi, McGreal et al
Development (2016) 143 (11), 1937-47 DOI: 10.1242/dev.135285
AI Summary: OriGene products contributed to this study by providing the Pax6 and Hsf4 cDNA clones in the CMV vectors pKW10 and pCMV6-XL6, respectively, which were used to investigate gene expression relevant to lens differentiation and denucleation.
Snippet: Pax6 and Hsf4 cDNAs were obtained in the CMV vectors pKW10 and pCMV6-XL6, respectively (Yang et al. 2006;OriGene)
Functional Analysis of HSF4 Mutations Found in Patients With Autosomal Recessive Congenital Cataracts
Merath, Ronchetti, Sidjanin
Invest. Ophthalmol. Vis. Sci. (2013) 54 (10), 6646-54 DOI: 10.1167/iovs.13-12283
Cited by 15
AI Summary: OriGene’s pCMV6-XL4 vector containing wild-type human HSF4b cDNA was used as the template for generating HSF4 constructs, enabling the study to functionally analyze mutant and wild-type HSF4 proteins in cellular assays.
Snippet: Materials and Methods. HSF4 cDNA Constructs. The WT human HSF4b cDNA in pCMV6-XL4 vector was purchased from OriGene Technologies, Inc. (Rockville, MD). Following digestion with EcoRI and SmaI, HSF4 cDNA was
Showing 1-3 of 3 papers.
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