RON (MST1R) (NM_002447) Human Untagged Clone

SKU SC309913

MST1R (untagged)-Human macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R)

Product Data

• Type: Human Untagged Clone
• Target Symbol: RON
• Synonyms: CD136; CDw136; NPCA3; PTK8; RON; SEA
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002447 edited; GAATTCGCACCAGTCGGGACCGCTGCTTAAATTTGGCCCAGTCCAGACCTCGAGTCGGGC; CCCCAGCCAGGCCCACGCCCAGGTCCAGGCCCAGGCCGGTAGGGATCCTCTAGGGTCCCA; GCTCGCCTCGATGGAGCTCCTCCCGCCGCTGCCTCAGTCCTTCCTGTTGCTGCTGCTGTT; GCCTGCCAAGCCCGCGGCGGGCGAGGACTGGCAGTGCCCGCGCACCCCCTACGCGGCCTC; TCGCGACTTTGACGTGAAGTACGTGGTGCCCAGCTTCTCCGCCGGAGGCCTGGTACAGGC; CATGGTGACCTACGAGGGCGACAGAAATGAGAGTGCTGTGTTTGTAGCCATACGCAATCG; CCTGCATGTGCTTGGGCCTGACCTGAAGTCTGTCCAGAGCCTGGCCACGGGCCCTGCTGG; AGACCCTGGCTGCCAGACGTGTGCAGCCTGTGGCCCAGGACCCCACGGCCCTCCCGGTGA; CACAGACACAAAGGTGCTGGTGCTGGATCCCGCGCTGCCTGCGCTGGTCAGTTGTGGCTC; CAGCCTGCAGGGCCGCTGCTTCCTGCATGACCTAGAGCCCCAAGGGACAGCCGTGCATCT; GGCAGCGCCAGCCTGCCTCTTCTCAGCCCACCATAACCGGCCCGATGACTGCCCCGACTG; TGTGGCCAGCCCATTGGGCACCCGTGTAACTGTGGTTGAGCAAGGCCAGGCCTCCTATTT; CTACGTGGCATCCTCACTGGACGCAGCCGTGGCTGCCAGCTTCAGCCCACGCTCAGTGTC; TATCAGGCGTCTCAAGGCTGACGCCTCGGGATTCGCACCGGGCTTTGTGGCGTTGTCAGT; GCTGCCCAAGCATCTTGTCTCCTACAGTATTGAATACGTGCACAGCTTCCACACGGGAGC; CTTCGTGTACTTCCTGACTGTACAGCCGGCCAGCGTGACAGATGATCCTAGTGCCCTGCA; CACACGCCTGGCACGGCTTAGCGCCACTGAGCCAGAGTTGGGTGACTATCGGGAGCTGGT; CCTCGACTGCAGATTTGCTCCAAAACGCAGGCGCCGGGGGGCCCCAGAAGGCGGACAGCC; CTACCCTGTGCTGCGGGTGGCCCACTCCGCTCCAGTGGGTGCCCAACTTGCCACTGAGCT; GAGCATCGCCGAGGGCCAGGAAGTACTATTTGGGGTCTTTGTGACTGGCAAGGATGGTGG; TCCTGGCGTGGGCCCCAACTCTGTCGTCTGTGCCTTCCCCATTGACCTGCTGGACACACT; AATTGATGAGGGTGTGGAGCGCTGTTGTGAATCCCCAGTCCATCCAGGCCTCCGGCGAGG; CCTCGACTTCTTCCAGTCGCCCAGTTTTTGCCCCAACCCGCCTGGCCTGGAAGCCCTCAG; CCCCAACACCAGCTGCCGCCACTTCCCTCTGCTGGTCAGTAGCAGCTTCTCACGTGTGGA; CCTATTCAATGGGCTGTTGGGACCAGTACAGGTCACTGCATTGTATGTGACACGCCTTGA; CAACGTCACAGTGGCACACATGGGCACAATGGATGGGCGTATCCTGCAGGTGGAGCTGGT; CAGGTCACTAAACTACTTGCTGTATGTGTCCAACTTCTCACTGGGTGACAGTGGGCAGCC; CGTGCAGCGGGATGTCAGTCGTCTTGGGGACCACCTACTCTTTGCCTCTGGGGACCAGGT; TTTCCAGGTACCTATCCAAGGCCCTGGCTGCCGCCACTTCCTGACCTGTGGGCGTTGCCT; AAGGGCATGGCATTTCATGGGCTGTGGCTGGTGTGGGAACATGTGCGGCCAGCAGAAGGA; GTGTCCTGGCTCCTGGCAACAGGACCACTGCCCACCTAAGCTTACTGAGTTCCACCCCCA; CAGTGGACCTCTAAGGGGCAGTACAAGGCTGACCCTGTGTGGCTCCAACTTCTACCTTCA; CCCTTCTGGTCTGGTGCCTGAGGGAACCCATCAGGTCACTGTGGGCCAAAGTCCCTGCCG; GCCACTGCCCAAGGACAGCTCAAAACTCAGACCAGTGCCCCGGAAAGACTTTGTAGAGGA; GTTTGAGTGTGAACTGGAGCCCTTGGGCACCCAGGCAGTGGGGCCTACCAACGTCAGCCT; CACCGTGACTAACATGCCACCGGGCAAGCACTTCCGGGTGGACGGCACCTCCGTGCTGAG; AGGCTTCTCTTTCATGGAGCCAGTGCTGATAGCAGTGCAACCCCTCTTTGGCCCACGGGC; AGGAGGCACCTGTCTCACTCTTGAAGGCCAGAGTCTGTCTGTAGGCACCAGCCGGGCTGT; GCTGGTCAATGGGACTGAGTGTCTGCTAGCACGGGTCAGTGAGGGGCAGCTTTTATGTGC; CACACCCCCTGGGGCCACGGTGGCCAGTGTCCCCCTTAGCCTGCAGGTGGGGGGTGCCCA; GGTACCTGGTTCCTGGACCTTCCAGTACAGAGAAGACCCTGTCGTGCTAAGCATCAGCCC; CAACTGTGGCTACATCAACTCCCACATCACCATCTGTGGCCAGCATCTAACTTCAGCATG; GCACTTAGTGCTGTCATTCCATGACGGGCTTAGGGCAGTGGAAAGCAGGCAGTGTGAGAG; GCAGCTTCCAGAGCAGCAGCTGTGCCGCCTTCCTGAATATGTGGTCCGAGACCCCCAGGG; ATGGGTGGCAGGGAATCTGAGTGCCCGAGGGGATGGAGCTGCTGGCTTTACACTGCCTGG; CTTTCGCTTCCTACCCCCACCCCATCCACCCAGTGCCAACCTAGTTCCACTGAAGCCTGA; GGAGCATGCCATTAAGTTTGAGTATATTGGGCTGGGCGCTGTGGCTGACTGTGTGGGTAT; CAACGTGACCGTGGGTGGTGAGAGCTGCCAGCACGAGTTCCGGGGGGACATGGTTGTCTG; CCCCCTGCCCCCATCCCTGCAGCTTGGCCAGGATGGTGCCCCATTGCAGGTCTGCGTAGA; TGGTGAATGTCATATCCTGGGTAGAGTGGTGCGGCCAGGGCCAGATGGGGTCCCACAGAG; CACGCTCCTTGGTATCCTGCTGCCTTTGCTGCTGCTTGTGGCTGCACTGGCGACTGCACT; GGTCTTCAGCTACTGGTGGCGGAGGAAGCAGCTAGTTCTTCCTCCCAACCTGAATGACCT; GGCATCCCTGGACCAGACTGCTGGAGCCACACCCCTGCCTATTCTGTACTCGGGCTCTGA; CTACAGAAGTGGCCTTGCACTCCCTGCCATTGATGGTCTGGATTCCACCACTTGTGTCCA; TGGAGCATCCTTCTCCGATAGTGAAGATGAATCCTGTGTGCCACTGCTGCGGAAAGAGTC; CATCCAGCTAAGGGACCTGGACTCTGCGCTCTTGGCTGAGGTCAAGGATGTGCTGATTCC; CCATGAGCGGGTGGTCACCCACAGTGACCGAGTCATTGGCAAAGGCCACTTTGGAGTTGT; CTACCACGGAGAATACATAGACCAGGCCCAGAATCGAATCCAATGTGCCATCAAGTCACT; AAGTCGCATCACAGAGATGCAGCAGGTGGAGGCCTTCCTGCGAGAGGGGCTGCTCATGCG; TGGCCTGAACCACCCGAATGTGCTGGCTCTCATTGGTATCATGTTGCCACCTGAGGGCCT; GCCCCATGTGCTGCTGCCCTATATGTGCCACGGTGACCTGCTCCAGTTCATCCGCTCACC; TCAGCGGAACCCCACCGTGAAGGACCTCATCAGCTTTGGCCTGCAGGTAGCCCGCGGCAT; GGAGTACCTGGCAGAGCAGAAGTTTGTGCACAGGGACCTGGCTGCGCGGAACTGCATGCT; GGACGAGTCATTCACAGTCAAGGTGGCTGACTTTGGTTTGGCCCGCGACATCCTGGACAG; GGAGTACTATAGTGTTCAACAGCATCGCCACGCTCGCCTACCTGTGAAGTGGATGGCGCT; GGAGAGCCTGCAGACCTATAGATTTACCACCAAGTCTGATGTGTGGTCATTTGGTGTGCT; GCTGTGGGAACTGCTGACACGGGGTGCCCCACCATACCGCCACATTGACCCTTTTGACCT; TACCCACTTCCTGGCCCAGGGTCGGCGCCTGCCCCAGCCTGAGTATTGCCCTGATTCTCT; GTACCAAGTGATGCAGCAATGCTGGGAGGCAGACCCAGCAGTGCGACCCACCTTCAGAGT; ACTAGTGGGGGAGGTGGAGCAGATAGTGTCTGCACTGCTTGGGGACCATTATGTGCAGCT; GCCAGCAACCTACATGAACTTGGGCCCCAGCACCTCGCATGAGATGAATGTGCGTCCAGA; ACAGCCGCAGTTCTCACCCATGCCAGGGAATGTACGCCGGCCCCGGCCACTCTCAGAGCC; TCCTCGGCCCACTTGACTTAGTTCTTGGGCTGGACCTGCTTAGCTGCCTTGAGCTAACCC; CAAGCTGCCTCTGGGCCATGCCAGGCCAGAGGGCAGTGGCCCTCCACCTTGTTCCTGCCC; TTTAACTTTCAGAGGCAATAGGTAAATGGGGCCCATTAGGTCCCTCACTCCACAGAGTGA; GCCAGTGAGGGCAGTCCTGCAACATGTATTTATGGAGTGCCTGCTGTGGACCCTGTCTTC; TGGGCACAGTGGACTCAGCAGTGACCACACCAACACTGACCCTTGAACCAATAAAGGAAC; AAATGACTATTAAAGCAAAAAAAAAAAAAAAAAACTCGAC;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002447 unedited; TGACTTCGTNCCGACTGNCAGTTCCGCGCAGCCAGGTCCCTGTGCACAAACTTCTGCTCT; GCCAGGTACTCCATGCCGCGGGCTACCTGCAGGCCAAAGCTGATGAGGTCCTTCACGGTG; GGGTTCCGCTGAGGTGAGCGGATGAACTGGAGCAGGTCACCGTGGCACATATAGGGCAGC; AGCACATGGGGCAGGCCCTCAGGTGGCAACATGATACCAATGAGAGCCAGCACATTCGGG; TGGTTCAGGCCACGCATGAGCAGCCCCTCTCGCAGGAAGGCCTCCACCTGCTGCATCTCT; GTGATGCGACTTAGTGACTTGATGGCACATTGGATTCGATTCTGGGCCTGGTCTATGTAT; TCTCCGTGGTAGACAACTCCAAAGTGGCCTTTGCCAATGACTCGGTCACTGTGGGTGACC; ACCCGCTCATGGGGAATCAGCACATCCTTGACCTCAGCCAAGAGCGCAGAGTCCAGGTCC; CTTAGCTGGATGGACTCTTTCCGCAGCAGTGGCACACAGGATTCATCTTCACTATCGGAG; AAGGATGCTCCATGGACACAAGTGGTGGAATCCAGACCATCAATGGCAGGGAGTGCAAGG; CCACTTCTGTAGTCAGAGCCCGAGTACAGAATAGGCAGGGGTGTGGCTCCAGCAGTCTGG; TCCAGGGATGCCAGGTCATTCAGGTTGGGAGGAAGAACTAGCTGCTTNCTCCGCCACCAG; TAGCTGAAGACCAGTGCAGTCGCCAGTGCAGCCACAAGCAGCAGCAAAGGCAGCAGGATA; CCAAGGAGCGTGCTCTGTGGGACCCCATCTGGCCCTGGCCGCAC;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002447 unedited; AGNANAGCACTGGGGNAGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAACAGCTAT; GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCTTTAATAGTCATTT; GTTCCTTTATTGGTTCAAGGGTCAGTGTTGGTGTGGTCACTGCTGAGTCCACTGTGCCCA; GAAGACAGGGTCCACAGCAGGCACTCCATAAATACATGTTGCAGGACTGCCCTCACTGGC; TCACTCTGTGGAGTGAGGGACCTAATGGGCCCCATTTACCTATTGCCTCTGAAAGTTAAA; GGGCAGGAACAAGGTGGAGGGCCACTGCCCTCTGGCCTGGCATGGCCCAGAGGCAGCTTG; GGGTTAGCTCAAGGCAGCTAAGCAGGTCCAGCCCAAGAACTAAGTCAAGTGGGCCGAGGA; GGCTCTGAGAGTGGCCGGGGCCGGCGTACATTCCCTGGCATGGGTGAGAACTGCGGCTGT; TCTGGACGCACATTCATCTCATGCGAGGTGCTGGGGCCCAAGTTCATGTAGGTTGCTGGC; AGCTGCACATAATGGTCCCCAAGCAGTGCAGACACTATCTGCTCCACCTCCCCCACTAGT; ACCTCTGAAGTGGGTCGCACTGCTGGGTCTGCCTCCCAGCATTGCTGCATCACTTGGTAC; AGAGAATCANGGCAATACTCANGCTGGGGCAGGCGCCGACCCTGGGCCACGAAGTGGGTT; AGGTCAAAAAGGTCAATGTGCCGGTATGGTGGGGCACCCCGTGTCACCAGTTTCCACAGC; CACCCCCCAAAAGACCACACATCAGACTTTGTGGGTAAATCTATAAGGGCTGCAGGCTCT; TCCACGCCG;
• Restriction Sites: Please inquire
• ACCN: NM_002447
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: There are 5 nucleotide differences between the OriGene clone and the NCBI reference ORF and 1 additional CAG tri-nucleotide repeat, none of which cause any frameshift. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 3 amino acids and the addition of one glutamine.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002447.1, NP_002438.1
• RefSeq Size: 4785 bp
• RefSeq ORF: 4203 bp
• Locus ID: 4486
• UniProt ID: Q04912
• Cytogenetics: 3p21.31
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]; Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as isoform Ron).