Tau (MAPT) (NM_005910) Human Untagged Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | Tau |
| Synonyms | DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; tau-40 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_005910 |
| Insert Size | 1326 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005910.3 |
| RefSeq Size | 5731 bp |
| RefSeq ORF | 1326 bp |
| Locus ID | 4137 |
| UniProt ID | P10636 |
| Cytogenetics | 17q21.31 |
| Domains | tubulin-binding |
| Protein Families | Druggable Genome |
| Protein Pathways | Alzheimer's disease, MAPK signaling pathway |
| MW | 45.8 kDa |
| Summary | This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. provided by RefSeq, Jul 2008 Transcript Variant: This variant (2) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (2) has identical N- and C-termini but lacks three segments, as compared to isoform 6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
"NM_005910" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC213312 | MAPT (Myc-DDK-tagged)-Human microtubule-associated protein tau (MAPT), transcript variant 2 | 10 ug |
$457.00
|
|
| RC213312L1 | Lenti ORF clone of Human microtubule-associated protein tau (MAPT), transcript variant 2, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC213312L2 | Lenti ORF clone of Human microtubule-associated protein tau (MAPT), transcript variant 2, mGFP tagged | 10 ug |
$757.00
|
|
| RC213312L3 | Lenti ORF clone of Human microtubule-associated protein tau (MAPT), transcript variant 2, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC213312L4 | Lenti ORF clone of Human microtubule-associated protein tau (MAPT), transcript variant 2, mGFP tagged | 10 ug |
$757.00
|
|
| RG213312 | MAPT (tGFP-tagged) - Human microtubule-associated protein tau (MAPT), transcript variant 2 | 10 ug |
$489.00
$657.00
|
|
Citations
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule-and lipid-binding properties of Tau
Ait-Bouziad, Chiki, Limorenko et al
bioRxiv (2020)
Ait-Bouziad, Chiki, Limorenko et al
bioRxiv (2020)
Cited by 4
Snippet: The K18 fragments were synthesized by GeneArt Gene Synthesis (Life Technologies) and cloned into the pT7-7 for bacterial expression. Tau 2N4R in pCMV6-XL5 vectors was obtained from OriGene Technologies, Inc. …
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene
Katsumata, Fardo, Bachstetter et al
J. Neuropathol. Exp. Neurol. (2019) 79 (1), 3-21 DOI: 10.1093/jnen/nlz116
Katsumata, Fardo, Bachstetter et al
J. Neuropathol. Exp. Neurol. (2019) 79 (1), 3-21 DOI: 10.1093/jnen/nlz116
AI Summary: OriGene products contributed to this study by providing the plasmids pCMV6-XL5 empty vector, pCMV6-XL5-MYC/DDK [Flag-tag]-AP2A2, and pCMV6-XL5-Tau, which were used in cell transfection experiments to investigate the roles of AP2A2 and Tau in Alzheimer’s disease pathology.
Snippet: …The following plasmids were used for transfections: pCMV6-XL5 empty vector;pCMV6-XL5-MYC/DDK [Flag-tag]-AP2A2, and pCMV6-XL5 -Tau (no tag)—all from Origene (Rockville, MD). According the manufacturer, the Tau plasmid expressed a transcript referent to accession number NM_005910, with an open reading frame of 1323 bp
Showing 1-2 of 2 papers.
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