FOXA2 (NM_153675) Human Untagged Clone

SKU SC306637

FOXA2 (untagged)-Human forkhead box A2 (FOXA2), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: FOXA2
• Synonyms: HNF-3-beta; HNF3B; TCF3B
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_153675 edited; GTGGCTGTTAAATTTTAAACTGCCATGCACTCGGCTTCCAGTATGCTGGGAGCGGTGAAG; ATGGAAGGGCACGAGCCGTCCGACTGGAGCAGCTACTATGCAGAGCCCGAGGGCTACTCC; TCCGTGAGCAACATGAACGCCGGCCTGGGGATGAACGGCATGAACACGTACATGAGCATG; TCGGCGGCCGCCATGGGCAGCGGCTCGGGCAACATGAGCGCGGGCTCCATGAACATGTCG; TCGTACGTGGGCGCTGGCATGAGCCCGTCCCTGGCGGGGATGTCCCCCGGCGCGGGCGCC; ATGGCGGGCATGGGCGGCTCGGCCGGGGCGGCTGGCGTGGCGGGCATGGGGCCGCACTTG; AGTCCCAGCCTGAGCCCGCTCGGGGGGCAGGCGGCCGGGGCCATGGGCGGCCTGGCCCCC; TACGCCAACATGAACTCCATGAGCCCCATGTACGGGCAGGCGGGCCTGAGCCGCGCCCGC; GACCCCAAGACCTACAGGCGCAGCTACACGCACGCAAAGCCGCCCTACTCGTACATCTCG; CTCATCACCATGGCCATCCAGCAGAGCCCCAACAAGATGCTGACGCTGAGCGAGATCTAC; CAGTGGATCATGGACCTCTTCCCCTTCTACCGGCAGAACCAGCAGCGCTGGCAGAACTCC; ATCCGCCACTCGCTCTCCTTCAACGACTGTTTCCTGAAGGTGCCCCGCTCGCCCGACAAG; CCCGGCAAGGGCTCCTTCTGGACCCTGCACCCTGACTCGGGCAACATGTTCGAGAACGGC; TGCTACCTGCGCCGCCAGAAGCGCTTCAAGTGCGAGAAGCAGCTGGCGCTGAAGGAGGCC; GCAGGCGCCGCCGGCAGCGGCAAGAAGGCGGCCGCCGGGGCCCAGGCCTCACAGGCTCAA; CTCGGGGAGGCCGCCGGGCCGGCCTCCGAGACTCCGGCGGGCACCGAGTCGCCTCACTCG; AGCGCCTCCCCGTGCCAGGAGCACAAGCGAGGGGGCCTGGGAGAGCTGAAGGGGACGCCG; GCTGCGGCGCTGAGCCCCCCAGAGCCGGCGCCCTCTCCCGGGCAGCAGCAGCAGGCCGCG; GCCCACCTGCTGGGCCCGCCCCACCACCCGGGCCTGCCGCCTGAGGCCCACCTGAAGCCG; GAACACCACTACGCCTTCAACCACCCGTTCTCCATCAACAACCTCATGTCCTCGGAGCAG; CAGCACCACCACAGCCACCACCACCACCAGCCCCACAAAATGGACCTCAAGGCCTACGAA; CAGGTGATGCACTACCCCGGCTACGGTTCCCCCATGCCTGGCAGCTTGGCCATGGGCCCG; GTCACGAACAAAACGGGCCTGGACGCCTCGCCCCTGGCCGCAGATACCTCCTACTACCAG; GGGGTGTACTCCCGGCCCATTATGAACTCCTCTTAAGAAGACGACGGCTTCAGGCCCGGC; TAACTCTGGCACCCCGGATCGAGGATAAGTGAGAGAGCAAGTGGGGGTCGAGACTTTGGG; GAGACGGTGTTGCAGAGACGCAAGGGAGAAGAAATCCATAACACCCCCACCCCAACACCC; CCAAGACAGCAGTCTTCCTTCACCCGCTGCAGCTGTTCCGTCCCAAACAGAGGGCCACAC; AGATACCCCACGTTCTATATAAGGAGGAAAACGGGAAAGAATATAAAGTTAAAAAAAAGC; CTCCGGTTTCCACTACTGTGTAGACTCCTGCTTCTTCAAGCACCTGCAGATTCTGATTTT; TTTGTTGTTGTTGTTCTCCTCCATTGCTGTTGTTGCAGGGAAGTCTTACTTAAAAAAAAA; AAAAAACTTTTGTGAGTGACTCGGTGTAAAACCATGTAGTTTTAACAGAACCAGAGGGTT; GTACTATTGTTTAAAAACAGGAAAAAAAATAATGTAAGGGTCTGTTGTAAATGACCAAGA; AAAAAAAAAAAAAAAAA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_153675 unedited; NGTTAGCTTTTGTAATACGACTTACTATTAGGGCGGCCGCGAATTCGCACNGGGTGGCTG; TTAAATTTTAAACTGCCATGCACTCGGCTTCCAGTATGCTGGGAGCGGTGAAGATGGAAG; GGCACGAGCCGTCCGACTGGAGCAGCTACTATGCAGAGCCCGAGGGCTACTCCTCCGTGA; GCAACATGAACGCCGGCCTGGGGATGAACGGCATGAACACGTACATGAGCATGTCGGCGG; CCGCCATGGGCAGCGGCTCGGGCAACATGAGCGCGGGCTCCATGAACATGTCGTCGTACG; TGGGCGCTGGCATGAGCCCGTCCCTGGCGGGGATGTCCCCCGGCGCGGGCGCCATGGCGG; GCATGGGCGGCTCGGCCGGGGCGGCTGGCGTGGCGGGCATGGGGCCGCACTTGAGTCCCA; GCCTGAGCCCGCTCGGGGGGCAGGCGGCCGGGGCCATGGGCGGCCTGGCCCCCTACGCCA; ACATGAACTCCATGAGCCCCATGTACGGGCAGGCGGGCCTGAGCCGCGCCCGCGACCCCA; AGACCTACAGGCGCAGCTACACGCACGCAAAGCCGCCCTACTCGTACATCTCGCTCATCA; CCATGGCCATCCAGCAGAGCCCCAACAAGATGCTGACGCTGAGCGAGATCTACCAGTGGA; TCATGGACCTCTTCCCCTTCTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCC; ACTCGCTCTCCTTCAACGACTGTTTCCTGAAGGTGCCCCGCTCGCCCGACAAGCCCGGCA; AGGGCTCCTTCTGGACCCTGCACCCTGACTCGGCAACATGTTCGAGAACGGCTGCTACCT; GCGCCGCCAGAAGCGCTTCAAGTGCGAGAAGCAGCTGGCGCTGAAAGGAGCCGCCAGCGC; CGNCCGCAGCGGCAAGAAGCGGCCGCCCGGG;
  3' Read Nucleotide Sequence

  >OriGene 3' genomic read for NM_153675 unedited; CATTGGNNGATGGCACTTNCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCC; ACCCGGGATCTGTTCAGGAAAAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTT; TTTTTTTTTTTCTTGGTCATTTACAACAGACCCTTACATTATTTTTTTTCCTGTTTTTAA; ACAATAGTACAACCCTCTGGTTCTGTTAAAACTACATGGTTTTACACCGAGTCACTCACA; AAAGTTTTTTTTTTTTTTTAAGTAAGACTTCCCTGCAACAACAGCAATGGAGGAGAACAA; CAACAACAAAAAAATCAGAATCTGCAGGTGCTTGAAGAAGCAGGAGTCTACACAGTAGTG; GAAACCGGAGGCTTTTTTTTAACTTTATATTCTTTCCCGTTTTCCTCCTTATATAGAACG; TGGGGTATCTGTGTGGCCCTCTGTTTGGGACGGAACAGCTGCAGCGGGTGAAGGAAGACT; GCTGTCTTGGGGGTGTTGGGGTGGGGGTGTTATGGATTTCTTCTCCCTTGCGTCTCTGCA; CACCGTCTCCCCAAAGTCTCGACCCCCACTTGCTCTCTCACTTATCCTCGATCCGGGGTG; CCAGAGTTAGCCGGGCCTGAAGCCGTCGTCTTCTTAAGAGAGTTCATAATGGGCCGGGAG; TACACCCCTGGTAGTAGGAGGTATCTGCGGCCCAGGGCGAGGCGTCCAGGCCCGTTTTGT; TCGTGACCGGGCCCATGGCCAAACCTGGCAGCATGGGGGGAACCCGTACCGGGGTAATGC; ATCACCTGTTCGTAAGCCTTGGAGGTCATTTTTTTGGCCCTGTGGTGGTGGTGCCTGTGG; TGGGTCCTGCTGCTCCCAGGACATGAAGGTTTTTAAGGGAAAACG;
• Restriction Sites: Please inquire
• ACCN: NM_153675
• Insert Size: 1900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_153675.1, NP_710141.1
• RefSeq Size: 2230 bp
• RefSeq ORF: 1374 bp
• Locus ID: 3170
• UniProt ID: Q9Y261
• Cytogenetics: 20p11.21
• Protein Families: Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young
• Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]; Transcript Variant: This variant (2) has a different splice pattern at the 5' end compared to transcript variant 1, resulting in translation initiation from a downstream AUG, and a shorter isoform (2) missing 6 aa from the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript matching the reference genomic sequence was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.