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RNF145 (NM_144726) Human Untagged Clone

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SKU
SC306192
RNF145 (untagged)-Human ring finger protein 145 (RNF145), transcript variant 2
  $697.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol RNF145
Vector pCMV6 series
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_144726, the custom clone sequence may differ by one or more nucleotides
ATGATGAGAAACCACAGAATTGCTAGTAGTTTATGTGGAGATCAGGTCTTCTCCAAGAAA
AAAAAAAAGAAAAAAAAAAACAACATGGCTGCAAAGGAGAAACTGGAGGCAGTGTTAAAT
GTGGCCCTGAGGGTGCCAAGCATCATGCTGTTGGATGTCCTGTACAGATGGGATGTCAGC
TCCTTTTTCCAGCAGATCCAAAGAAGTAGCCTTAGTAATAACCCTCTTTTCCAGTATAAG
TATTTGGCTCTTAATATGCATTATGTAGGTTATATCTTAAGTGTGGTGCTGCTAACATTG
CCCAGGCAGCATCTGGTTCAGCTTTATCTATATTTTTTGACTGCTCTGCTCCTCTATGCT
GGACATCAAATTTCCAGGGACTATGTTCGGAGTGAACTGGAGTTTGCCTATGAGGGACCA
ATGTATTTAGAACCTCTCTCTATGAATCGGTTTACCACAGCCTTAATAGGTCAGTTGGTG
GTGTGTACTTTATGCTCCTGTGTCATGAAAACAAAGCAGATTTGGCTGTTTTCAGCTCAC
ATGCTTCCTCTGCTAGCACGACTCTGCCTTGTTCCTTTGGAGACAATTGTTATCATCAAT
AAATTTGCTATGATTTTTACTGGATTGGAAGTTCTCTATTTTCTTGGGTCTAATCTTTTG
GTACCTTATAACCTTGCTAAATCTGCATACAGAGAATTGGTTCAGGTAGTGGAGGTATAT
GGCCTTCTCGCCTTGGGAATGTCCCTGTGGAATCAACTGGTAGTCCCTGTTCTTTTCATG
GTTTTCTGGCTCGTCTTATTTGCTCTTCAGATTTACTCCTATTTCAGTACTCGAGATCAG
CCTGCATCACGTGAGAGGCTTCTTTTCCTTTTTCTGACAAGTATTGCGGAATGCTGCAGC
ACTCCTTACTCTCTTTTGGGTTTGGTCTTCACGGTTTCTTTTGTTGCCTTGGGTGTTCTC
ACACTCTGCAAGTTTTACTTGCAGGGTTATCGAGCTTTCATGAATGATCCTGCCATGAAT
CGGGGCATGACAGAAGGAGTAACGCTGTTAATCCTGGCAGTGCAGACTGGGCTGATAGAA
CTGCAGGTTGTTCATCGGGCATTCTTGCTCAGTATTATCCTTTTCATTGTCGTAGCTTCT
ATCCTACAGTCTATGTTAGAAATTGCAGATCCTATTGTTTTGGCACTGGGAGCATCTAGA
GACAAGAGCTTGTGGAAACACTTCCGTGCTGTAAGCCTTTGTTTATTTTTATTGGTATTC
CCTGCTTATATGGCTTATATGATTTGCCAGTTTTTCCACATGGATTTTTGGCTTCTTATC
ATTATTTCCAGCAGCATTCTTACCTCTCTTCAGGTTCTGGGAACACTTTTTATTTATGTC
TTATTTATGGTTGAGGAATTCAGAAAAGAGCCAGTGGAAAACATGGATGATGTCATCTAC
TATGTGAATGGCACTTACCGCCTGCTGGAGTTTCTTGTGGCCCTCTGTGTGGTGGCCTAT
GGCGTCTCAGAGACCATCTTTGGAGAATGGACAGTGATGGGCTCAATGATCATCTTCATT
CATTCCTACTATAACGTGTGGCTTCGGGCCCAGCTGGGGTGGAAGAGCTTTCTTCTCCGC
AGGGATGCTGTGAATAAGATTAAATCGTTACCCATTGCTACGAAAGAGCAGCTTGAGAAA
CACAATGATATTTGTGCCATCTGTTATCAGGACATGAAATCTGCTGTGATCACGCCTTGC
AGTCATTTTTTCCATGCAGGCTGTCTTAAGAAATGGCTGTATGTCCAGGAGACCTGCCCT
CTGTGCCACTGCCATCTGAAAAACTCCTCCCAGCTTCCAGGATTAGGAACTGAGCCAGTT
CTACAGCCTCATGCTGGAGCTGAGCAAAACGTCATGTTTCAGGAAGGTACTGAACCCCCA
GGCCAGGAGCATACTCCAGGGACCAGGATACAGGAAGGTTCCAGGGACAATAATGAGTAC
ATTGCCAGACGACCAGATAACCAGGAAGGGGCTTTTGACCCCAAAGAATATCCTCACAGT
GCGAAAGATGAAGCACATCCTGTTGAATCAGCCTAG
Restriction Sites Please inquire |
ACCN NM_144726
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_144726.1, NP_653327.1
RefSeq Size 3362 bp
RefSeq ORF 2076 bp
Locus ID 153830
UniProt ID Q96MT1
Cytogenetics 5q33.3
Domains RING
Protein Families Druggable Genome, Transmembrane
Summary E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis.UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
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Documents
Resources
"NM_144726" in other vectors (4)
SKU Description Size Price
RC216033 RNF145 (Myc-DDK-tagged)-Human ring finger protein 145 (RNF145), transcript variant 2 10 ug
$589.00 $633.00
RC216033L3 Lenti-ORF clone of RNF145 (Myc-DDK-tagged)-Human ring finger protein 145 (RNF145), transcript variant 2 10 ug
$933.00
RC216033L4 Lenti-ORF clone of RNF145 (mGFP-tagged)-Human ring finger protein 145 (RNF145), transcript variant 2 10 ug
$933.00
RG216033 RNF145 (tGFP-tagged) - Human ring finger protein 145 (RNF145), transcript variant 2 10 ug
$833.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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