GAB2 (NM_080491) Human Untagged Clone
$620.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | GAB2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_080491 |
| Insert Size | 2700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | There are 4 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_080491.1, NP_536739.1 |
| RefSeq Size | 6007 bp |
| RefSeq ORF | 2031 bp |
| Locus ID | 9846 |
| UniProt ID | Q9UQC2 |
| Cytogenetics | 11q14.1 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis |
| Summary | This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. provided by RefSeq, Nov 2009 Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_080491" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC215435 | GAB2 (Myc-DDK-tagged)-Human GRB2-associated binding protein 2 (GAB2), transcript variant 1 | 10 ug |
$619.00
|
|
| RC215435L1 | Lenti ORF clone of Human GRB2-associated binding protein 2 (GAB2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$919.00
|
|
| RC215435L2 | Lenti ORF clone of Human GRB2-associated binding protein 2 (GAB2), transcript variant 1, mGFP tagged | 10 ug |
$919.00
|
|
| RC215435L3 | Lenti ORF clone of Human GRB2-associated binding protein 2 (GAB2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$919.00
|
|
| RC215435L4 | Lenti ORF clone of Human GRB2-associated binding protein 2 (GAB2), transcript variant 1, mGFP tagged | 10 ug |
$919.00
|
|
| RG215435 | GAB2 (tGFP-tagged) - Human GRB2-associated binding protein 2 (GAB2), transcript variant 1 | 10 ug |
$789.00
$819.00
|
|
Citations
GAB2 regulates type 2 T helper cell differentiation in humans
Wang, Nestor, Benson et al
Cytokine (2017) 96, 234-237 DOI: 10.1016/j.cyto.2017.04.027
Wang, Nestor, Benson et al
Cytokine (2017) 96, 234-237 DOI: 10.1016/j.cyto.2017.04.027
AI Summary: In this study, OriGene’s pCMV6-XL4-GAB2 plasmid was used to ectopically express GAB2 in human T cells, enabling the authors to demonstrate GAB2’s role in regulating Th2 cell cytokine expression.
Snippet: Freshly isolated naive CD4 + T Cells were either transfected with non-targeting control siRNAs, or siRNAs targeting Gab2 (1 µM) for knocking down of GAB2, or transfected with either pCMV6-XL4-GAB2 (Origene) or pCMV6-XL4 plasmids (2 µg) for ectopic expression ... All 2 versions Cite SaveSaving
Gab2-mediated signaling promotes melanoma metastasis
Horst, Gruvberger-Saal, Hopkins et al
Am J Pathol (2009) 174 (4), 1524-33 DOI: 10.2353/ajpath.2009.080543
Horst, Gruvberger-Saal, Hopkins et al
Am J Pathol (2009) 174 (4), 1524-33 DOI: 10.2353/ajpath.2009.080543
Cited by 84
AI Summary: OriGene products, specifically Gab2 cDNA (SC119690) and Gab2 shRNA (TF313408), were used in this study to overexpress and silence Gab2 in melanoma cells, enabling the authors to demonstrate Gab2’s role in promoting melanoma cell migration, invasion, and metastasis.
Showing 1-2 of 2 papers.
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