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INAVA (NM_018265) Human Untagged Clone

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SKU
SC304571
C1orf106 (untagged)-Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1
  $993.00
3 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol INAVA
Synonyms C1orf106
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>SC304571 representing NM_018265.
Blue=Insert sequence Red=Cloning site Green=Tag(s)

GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
ATGCCCCAGGGGACAGATGTCTTGGGATCTTTAACATTTGGGATGCTGCAAATGCCGAAGTTAAATGAA
ATACCTCCGGGGAGGGCAGGCCGCAGGGAGGCTCGGGGGGAGGGAAGATGGCCTGGACAAACAGGTCCT
GAAGCTGCGAGGCTGGAGTGGAGGGCGCAGGGGCAGGCGGGCGGCGCCAGAGCTCCATGGGACAGCTGG
GGAAGCTCCAGGCTACCTACACAACCTGGCCCAGGCTGGTCACGGTGTCCCCCCTCCCTGCTCTGTGCC
CTCTCCTTCCAGAAATCCACCATGGAGAGTAAGGATGAGGTCAGCGACACCGACAGTGGCATCATCCTG
CAGTCTGGCCCCGACAGCCCGGTCTCCCCAATGAAGGAGCTGACCCATGCAGTGCACAAGCAGCAGAGG
GCCCTGGAAGCGAGGCTGGAGGCCTGCCTGGAGGAGCTGAGGAGACTCTGCCTTCGGGAAGCGGAGCTG
ACGGGCACCTTGCCAGCGGAGTATCCCCTCAAACCAGGGGAAAAGGCCCCCAAGGTTCGCCGCAGGATC
GGAGCGGCTTACAAACTGGATGACTGGGCCTTGCACAGAGAGGACCCCCTAAGCAGCCTGGAGCGCCAG
CTGGCCCTGCAGCTGCAGATCACAGAGGCAGCCCGTCGGCTGTGCCTGGAGGAGAACCTCAGCAGGCAG
GCTCGGCGGCAGCGGAAGCACTCCATGCTGCAGGAGGAGAAGAAGCTGCAGGAGCTCCAGCGCTGCCTG
GTCGAGCGGCGGCGCAATAGCGAGCCACCTCCGGCTGCTGCTCTCCCCCTGGGCCGAGAGCTCAGTGCC
TCTGATGACAGCTCCCTGTCAGATGGGCTCCTCCTGGAGGAAGAGGAATCCCAAGTGCCAAAACCTCCT
CCAGAGTCTCCAGCCCCACCTTCTCGGCCTCTCCCACCCCAAACCCTTGAGGGTCTGCAGCCAACAGGA
CCTGAGGCTGGGAGCCCAGAACGGGCTCCAGTCCAGAACAGCCCCTGGAAGGAAACCAGCCTGGACCAC
CCCTATGAGAAGCCCAGGAAGTCTTCTGAGCCCTGGAGCGAGTCCAGCAGCCCAGCCACCACACCACAG
GATGGGCCCAGTGCCTCCAGCCTGTGGCTTCTGGAGCCTGCCTCCTACCACGTGGTTCCCATCCGTGGT
GTTCCTGGCCAGTGGCAGGGCCGCACCAGTGCCCCAGCCACCCCTGAGATACAGGGGAGGAGGGGCCAG
TCGCAGTCTCTGAGGGTGGATTCCTTCCGGGCGGGTCCTGAGGGCCGAGGTCGCAGCGCCTTTCCCCGC
CGCCGCCCCACTCACTACACGGTGACAGTGCCAGATTCCTGCTTTCCCGCGACCAAGCCCCCGCTGCCC
CACGCCGCCTGCCACTCCTGCTCAGAAGACAGTGGCTCTGACGTCTCCAGCATCTCCCACCCCACTTCG
CCGGGCAGCAGCAGCCCCGACATCTCCTTTCTGCAGCCTCTCTCCCCTCCCAAGACCCATCGTCACCGC
GGGGCCTGGGTCCCAGCCGGCAGCAGAGAGCTGGTCGCCCACCACCCCAAGCTACTGCTGCCGCCTGGC
TATTTCCCGGCGGGGCGGTACGTGGTGGTGGCTGAGAGCCCCCTGCCGCCTGGCGAGTGGGAGCTGCGC
CGCGCAGCCCCGGGCCCTGCTTACGAGGAGGAGGGCACTCCCCTGCGCTACCAGCGTCTGGTGCCCTCC
CGCAGCCGCATCGTGCGGACGCCCTCCCTGAAGGACAGCCCGGCAGGCCGGGGGCTCAGCAAGGCCGCC
GTGTCCGAGGAGCTCAAGTGGTGGCACGAGCGTGCACGCCTCCGGAGCACCCGCCCCCACTCACTGGAC
CGCCAAGGAGCTTTCCGGGTCAGGAGCCTGCCCCTTGGGAGAGAGGGCTTCGGACGAGCCCTGGGACCC
CGGGCACAGGTGCCCACAGTTTGTGTGCTGCGGAGATCGCCTGATGGGGCCCCTGTGCAAGTCTTTGTA
CCTGAAAAAGGAGAGATCATCAGCCAGGTGTAA
ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT
TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites SgfI-MluI |
ACCN NM_018265
Insert Size 2034 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_018265.3
RefSeq Size 4161 bp
RefSeq ORF 2034 bp
Locus ID 55765
UniProt ID Q3KP66
Cytogenetics 1q32.1
MW 74.3 kDa
Summary Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
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Documents
Resources
"NM_018265" in other vectors (6)
SKU Description Size Price
RC215863 C1orf106 (Myc-DDK-tagged)-Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1 10 ug
$925.00
RC215863L1 Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, Myc-DDK-tagged 10 ug
$1,225.00
RC215863L2 Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, mGFP tagged 10 ug
$1,225.00
RC215863L3 Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, Myc-DDK-tagged 10 ug
$1,225.00
RC215863L4 Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, mGFP tagged 10 ug
$1,225.00
RG215863 C1orf106 (tGFP-tagged) - Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1 10 ug
$1,125.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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