CBX2 (NM_005189) Human Untagged Clone
$496.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | CBX2 |
| Synonyms | CDCA6; M33; SRXY5 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_005189 |
| Insert Size | 1600 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | It was fully sequenced and ORF exactly matches with that of NM_005189.1. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005189.1, NP_005180.1 |
| RefSeq Size | 4192 bp |
| RefSeq ORF | 1599 bp |
| Locus ID | 84733 |
| UniProt ID | Q14781 |
| Cytogenetics | 17q25.3 |
| Protein Families | Transcription Factors |
| Summary | This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.provided by RefSeq, Mar 2010 Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005189" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC222700 | CBX2 (Myc-DDK-tagged)-Human chromobox homolog 2 (CBX2), transcript variant 1 | 10 ug |
$495.00
|
|
| RC222700L1 | Lenti-ORF clone of CBX2 (Myc-DDK-tagged)-Human chromobox homolog 2 (CBX2), transcript variant 1 | 10 ug |
$795.00
|
|
| RC222700L2 | Lenti-ORF clone of CBX2 (mGFP-tagged)-Human chromobox homolog 2 (CBX2), transcript variant 1 | 10 ug |
$795.00
|
|
| RC222700L3 | Lenti-ORF clone of CBX2 (Myc-DDK-tagged)-Human chromobox homolog 2 (CBX2), transcript variant 1 | 10 ug |
$795.00
|
|
| RC222700L4 | Lenti-ORF clone of CBX2 (mGFP-tagged)-Human chromobox homolog 2 (CBX2), transcript variant 1 | 10 ug |
$795.00
|
|
| RG222700 | CBX2 (tGFP-tagged) - Human chromobox homolog 2 (CBX2), transcript variant 1 | 10 ug |
$695.00
|
|
Citations
The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach
Bouazzi, Sproll, Eid et al
Sci Rep (2019) 9 (1), 17033 DOI: 10.1038/s41598-019-53370-4
Bouazzi, Sproll, Eid et al
Sci Rep (2019) 9 (1), 17033 DOI: 10.1038/s41598-019-53370-4
Cited by 24
AI Summary: In this study, OriGene products—CBX2.1 plasmid (SC303599), C-Myc-CBX2.2 plasmid (RC216313), and the pCMV6-empty control plasmid (PS100010)—were used to transfect human granulosa cells, enabling the functional analysis of CBX2 isoforms in ovarian gene regulation.
Snippet: …Cells were transfected by 2 µg of plasmids encoding for CBX2.1 (SC303599, OriGene Rockville, Maryland, USA), C-Myc-CBX2.2 (RC216313 OriGene Rockville, Maryland, USA) and pCMV6-empty plasmid was used as a control vector (PS100010 OriGene Rockville, Maryland, USA). …siRNA duplex for CBX2 isoforms silencing was designed to alter specifically CBX2.1 and CBX2.2 so that siCBX2.1-oligos are not targeting CBX2.2 and vice-versa (si-oligo sequences are available upon request)
CBX2-dependent transcriptional landscape: implications for human sex development and its defects
Sproll, Eid, Biason-Lauber
Sci Rep (2019) 9 (1), 16552 DOI: 10.1038/s41598-019-53006-7
Sproll, Eid, Biason-Lauber
Sci Rep (2019) 9 (1), 16552 DOI: 10.1038/s41598-019-53006-7
AI Summary: OriGene's pCMV6-XL5 vector containing CBX2.1 cDNA (NM_005189) was used for CBX2.1 overexpression experiments, enabling the study of CBX2.1's role and downstream targets in human sex development.
Snippet: mentary DNA of CBX2.1 ({"type":"entrez-nucleotide","attrs":{"text":"NM_005189","term_id":"1519312113","term_text":"NM_005189"}}NM_005189 [/nuccore/NM_005189]) in a pCMV6-XL5 vector was purchased from Origene (Rockville, Maryland, United States). 4 µl/µg DNA of Fugene 6 (Promega, Madison, Wisconsin, United States) was used for the transfection of NT2-D1 cells with either CBX2.1 or an EV as a co
CBX2 and the Ovary: Novel Insights into Regulatory Networks in Humans
Bouazzi, Franco, Maret et al
Journal of Gynecology & Reproductive Medicine (2018) 2 (1)
Bouazzi, Franco, Maret et al
Journal of Gynecology & Reproductive Medicine (2018) 2 (1)
Showing 1-3 of 3 papers.
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